中国药房2024，Vol.35Issue(11)：1396-1402,7.DOI:10.6039/j.issn.1001-0408.2024.11.20
莪术油化学成分、抗肿瘤作用及制剂研究进展
Research progress on the chemical components,anti-tumor effects and preparations of zedoary turmeric oil
摘要
Abstract
Zedoary turmeric oil,volatile oil extracted from zedoary turmeric,composed mainly of monoterpenes(including α-pinene,β-pinene,etc.)and sesquiterpenes(including β-elemene,zedoary alcohol,zedoary ketone,etc.),and has been used in clinical practice to treat various malignant tumors such as ovarian cancer,cervical carcinoma,colorectal cancer,lung cancer and liver cancer.Zedoary turmeric oil regulates vascular endothelial growth factor and nuclear factors-κB,signal transducers and activator of transcription 3 signaling pathways to play a role in inhibiting tumor angiogenesis,inhibiting tumor cell proliferation,inducing tumor cell apoptosis,and blocking cell cycle.However,due to its insolubility in water and poor stability,its clinical application is limited;the application of new formulations and technologies such as liposomes,microspheres,and nanoemulsion improves the solubility and stability of zedoary turmeric oil.This paper summarizes recent research progress on the chemical composition,anti-tumor effects,and formulations of zedoary turmeric oil,both domestically and internationally,providing a reference for further expanding the clinical application and formulation development of zedoary turmeric oil in the anti-tumor field.关键词
莪术油/化学成分/抗肿瘤/制剂Key words
zedoary turmeric oil/chemical components/anti-tumor/preparation分类
医药卫生引用本文复制引用
华天琦,刘宇灵,林龙飞,廖倩,李慧..莪术油化学成分、抗肿瘤作用及制剂研究进展[J].中国药房,2024,35(11):1396-1402,7.基金项目
国家重点研发计划项目(No.2022YFC3501900) （No.2022YFC3501900）
江西省重点研发计划项目(No.20232BBG70016) （No.20232BBG70016）
中国中医科学院科技创新工程课题(No.CI2021A04301) （No.CI2021A04301）
