中国医学创新2024，Vol.21Issue(15)：29-33,5.DOI:10.3969/j.issn.1674-4985.2024.15.007
清热止带方坐浴联合乳杆菌活菌胶囊治疗湿热下注型绝经后萎缩性阴道炎的临床效果及对性激素的影响
Clinical Effect of Sitz Bath with Qingre Zhidai Prescription Combined with Live Lactobacillus Capsules in the Treatment of Postmenopausal Atrophic Vaginitis with Pattern of Dampness-heat Diffusing Downward and Its Influence on Sex Hormone
摘要
Abstract
Objective:To investigate the clinical effect of sitz bath with Qingre Zhidai Prescription combined with Live Lactobacillus Capsules in the treatment of postmenopausal atrophic vaginitis with pattern of dampness-heat diffusing downward and its influence on sex hormone.Method:A total of 130 patients with postmenopausal atrophic vaginitis with pattern of dampness-heat diffusing downward treated in Weifang Hospital of Traditional Chinese Medicine from April 2019 to November 2022 were selected and randomly divided into control group(n=65)and observation group(n=65).The control group was given Live Lactobacillus Capsules,and the observation group was given Qingre Zhidai Prescription sitz bath on the basis of Live Lactobacillus Capsules.Both groups were treated for 4 weeks.The clinical efficacy,sex hormone[follicle-stimulating hormone(FSH),estradiol(E2)],immune function indexes[immunoglobulin M(IgM),immunoglobulin G(IgG),immunoglobulin A(IgA)],inflammatory factors[interleuin-8(IL-8),interleukin-4(IL-4)and C reactive protein(CRP)]in vaginal discharge and adverse reactions were compared between the two groups.Result:The total effective rate of observation group(95.38%)was higher than that of control group(84.62%)(P<0.05).After treatment,FSH were decreased and E2 were increased in both groups,FSH in observation group was lower than that in control group,while E2 was higher than that in control group(P<0.05).After treatment,the levels of IgM,IgG and IgA in both groups were increased,and the levels of IgM,IgG and IgA in observation group were higher than those in control group(P<0.05).After treatment,the levels of IL-8,IL-4 and CRP in vaginal discharge of both groups were decreased,and the levels of IL-8,IL-4 and CRP in observation group were lower than those in control group(P<0.05).The incidence of adverse reactions in observation group(6.15%)was lower than that in control group(18.46%)(P<0.05).Conclusion:The effect of sitz bath with Qingre Zhidai Prescription combined with Live Lactobacillus Capsules in the treatment of postmenopausal atrophic vaginitis with pattern of dampness-heat diffusing downward is exact,which can improve sex hormones and immune function,inhibit vaginal inflammatory reaction,and have good safety.关键词
清热止带方/乳杆菌活菌胶囊/绝经后萎缩性阴道炎/性激素Key words
Qingre Zhidai Prescription/Live Lactobacillus Capsules/Postmenopausal atrophic vaginitis/Sex hormone引用本文复制引用
王国宁,李扬,王丹丹,魏延菊..清热止带方坐浴联合乳杆菌活菌胶囊治疗湿热下注型绝经后萎缩性阴道炎的临床效果及对性激素的影响[J].中国医学创新,2024,21(15):29-33,5.基金项目
潍坊市科技计划发展项目(2022YX020) （2022YX020）
