中国医学创新2024，Vol.21Issue(15)：143-147,5.DOI:10.3969/j.issn.1674-4985.2024.15.034
非小细胞肺癌患者血清长链非编码RNA及血管内皮生长因子的表达变化及相关性研究
Study on the Expression Changes and Correlation of Serum Long Non-coding RNA and Vascular Endothelial Growth Factor in Patients with Non-small Cell Lung Carcinoma
陈丽丽 1李明 1王文怡1
作者信息
- 1. 武汉科技大学附属天佑医院检验科 湖北 武汉 430064
- 折叠
摘要
Abstract
Objective:To investigate the expression changes and correlation of serum long non-coding RNA(lncRNA)and vascular endothelial growth factor(VEGF)in patients with non-small cell lung carcinoma.Method:A total of 90 patients with non-small cell lung carcinoma admitted to Tianyou Hospital Affiliated to Wuhan University of Science&Technology from January 2020 to May 2023 were included in the observation group,and 40 patients with benign lung lesions admitted during the same period were included in the control group.The expression levels of serum lncRNA(lncRNA H19,lncRNA DANCR and lncRNA ANRIL)and VEGF(VEGF-A,VEGF-C and VEGF-D)were detected and compared between the two groups.The expression levels of serum lncRNA and VEGF in patients with different gender,age,disease staging,differentiation degree and lymph node metastasis situation were compared in the observation group.Pearson correlation was used to analyze the correlation between serum lncRNA and VEGF in patients with non-small cell lung carcinoma.Result:Serum lncRNA and VEGF in observation group were significantly higher than those in control group(P<0.05).There were significant differences in serum lncRNA and VEGF in patients with disease staging and lymph node metastasis situation in the observation group(P<0.05).Pearson correlation analysis showed that serum lncRNA were positively correlated with VEGF in patients with non-small cell lung carcinoma(P<0.05).Conclusion:lncRNA H19,lncRNA DANCR,lncRNA ANRIL and VEGF are all highly expressed in patients with non-small cell lung carcinoma,and the above lncRNA are positively correlated with VEGF,which have certain value in the early diagnosis of non-small cell lung carcinoma.关键词
非小细胞肺癌/长链非编码RNA/血管内皮生长因子/相关性Key words
Non-small cell lung carcinoma/Long non-coding RNA/Vascular endothelial growth factor/Correlation引用本文复制引用
陈丽丽,李明,王文怡..非小细胞肺癌患者血清长链非编码RNA及血管内皮生长因子的表达变化及相关性研究[J].中国医学创新,2024,21(15):143-147,5.
