中医康复2024，Vol.1Issue(8)：49-54,59,7.DOI:10.19787/j.issn.2097-3128.2024.08.009
炎症性关节病与心血管疾病因果关系的双向孟德尔随机化研究
Bidirectional Mendelian Randomization Study of the Causal Relationship between In-flammatory Joint Disease and Cardiovascular Disease
摘要
Abstract
Objective:To explore the causal relationship between Inflammatory joint disease(IJD)and cardiovascular disease(CVD).Methods:Single nucleotide polymorphisms(SNPs)strongly associated with IJD and CVD were collected as instrumental variables(IVs)in a genome-wide as-sociation study(GWAS).Inverse variance weighted(IVW)was employed as the primary approach for conducting MR analysis,while auxiliary analy-ses were performed using weighted median(WME),MR-Egger regression(MER),weighted mode(WM),and simple mode(SM)to assess the causal relationship between IJD and CVD.Sensitivity analyses were performed to assess the robustness of the result.Results:The present study considered IJD as an exposure variable,utilizing a set of 10 SNPs associated with CVD as instrumental variables.IVW results showed a positive causal relation-shipn between IJD and CVD(OR=2.14,95%CI:1.11～4.16,P=0.0230951,P<0.05).Cochran's Q test showed no heterogeneity(P>0.05),and MR-Egger regression did not reveal horizontal pleiotropy of instrumental variables(P>0.05).The MR analysis results were robust after removing SNP one by one.MR analysis shows that IJD and CVD do not support a reverse causal relationship(OR=0.99,95%CI:0.99～1.00,P=0.4686601,P>0.05).Conclusion:This MR study demonstrates the causal relationship between IJD and CVD,but the reverse causal relationship is not established.The aim is to promote understanding of the relationship between IJD and CVD,aand early prevention and clinical intervention for CVD should be consid-ered in IJD patients.关键词
孟德尔随机化/炎症性关节炎/心血管疾病/因果关系/循证医学Key words
mendelian randomization/inflammatory joint disease/cardiovascular disease/causal relationship/evidence-based medicine分类
医药卫生引用本文复制引用
陈晶晶,宋思琦,朱宇晨,王清松,冷雯雯,胡毓诗..炎症性关节病与心血管疾病因果关系的双向孟德尔随机化研究[J].中医康复,2024,1(8):49-54,59,7.基金项目
四川省专家工作站资助课题(A2020-SZJYYA01) （A2020-SZJYYA01）
