大学化学2024，Vol.39Issue(5)：238-242,5.DOI:10.3866/PKU.DXHX202311066
光引发格氏试剂合成与三苯甲醇制备实验改进
Photoinitiated Grignard Reagent Synthesis and Experimental Improvement in Triphenylmethanol Preparation
摘要
Abstract
In university organic chemistry experiments,the classic teaching project of synthesizing triphenylmethanol by reacting Grignard reagent with benzoate often encounters challenges with the conventional method of initiating the reaction using iodine heating.This approach is difficult to control and prone to generating by-products like biphenyl,leading to low yields.Furthermore,some students may fail to obtain the Grignard reagent,resulting in experiment failure.In this study,we propose a photoinitiated method for synthesizing the Grignard reagent,eliminating the need for iodine heating.Under 520 nm LED irradiation,bromobenzene reacts directly with magnesium to form phenylmagnesium bromide without requiring external heating,even at temperatures as low as-10 ℃.This cost-effective and readily available light source significantly shortens synthesis time,improves yield,and enhances experimental success rates.Therefore,this innovative approach holds promise for wider adoption and application in university settings.关键词
三苯甲醇/格氏试剂/光化学/改进Key words
Triphenylmethanol/Grignard reagent/Photochemistry/Improvement分类
社会科学引用本文复制引用
成万民,都娟,刘佩雯,蒋逸云,江洪..光引发格氏试剂合成与三苯甲醇制备实验改进[J].大学化学,2024,39(5):238-242,5.基金项目
国家自然科学基金(22301091) （22301091）
