大学化学2024，Vol.39Issue(5)：243-250,8.DOI:10.3866/PKU.DXHX202311074
经典肉桂酸合成实验的改进与拓展
Refinement and Expansion of the Classic Cinnamic Acid Synthesis Experiment
摘要
Abstract
The experiment for synthesizing cinnamic acid is a crucial foundational experiment in the current"Organic Chemistry Experiment"curriculum in higher education.However,during its implementation,several issues have emerged,including the unpleasant odor of residual benzaldehyde,sensitivity of raw materials to water,procurement challenges,and the generation of numerous high-temperature by-products.In response to these challenges,this paper proposes improvements to the classic cinnamic acid synthesis experiment.A homogeneous reaction system comprising benzaldehyde/malonic acid/triethylenediamine was employed to synthesize cinnamic acid.Additionally,a post-treatment method involving washing with sodium bisulfite was introduced to eliminate residual benzaldehyde,thereby aligning the experiment with modern teaching practices and the principles of green chemistry.The enhanced experiment not only effectively mitigates the odor issue associated with residual benzaldehyde but also offers advantages such as improved raw material stability,lower costs,and simplified post-treatment procedures.Furthermore,by incorporating spectroscopic characterization and column chromatography,the experiment can be expanded into a comprehensive 8-hour laboratory session targeting the synthesis of the fine chemical ferulic acid,thus enhancing the development of students'overall chemical proficiency.关键词
肉桂酸/合成实验/亚硫酸氢钠/实验创新Key words
Cinnamic acid/Synthesis experiment/Sodium bisulfite/Experimental innovation分类
社会科学引用本文复制引用
高庆英,罗涛,苏建源,俞超凡,李家柱,焉炳飞,李文佐,张震,刘义..经典肉桂酸合成实验的改进与拓展[J].大学化学,2024,39(5):243-250,8.基金项目
山东省高等教育本科教学改革研究项目(Z2021070) （Z2021070）
烟台大学教学改革研究项目(jyxm2021014) （jyxm2021014）
