大学化学2024，Vol.39Issue(5)：201-208,8.DOI:10.3866/PKU.DXHX202311033
可见光介导多组分一锅法合成仲胺化合物及其机理探究
Visible-Light-Mediated One-Pot Synthesis of Secondary Amines and Mechanistic Exploration
摘要
Abstract
This experiment integrates cutting-edge research from the field of organic photochemistry into undergraduate laboratory instruction.Utilizing benzaldehyde,aniline,and 4-isopropyl-1,4-dihydropyridines as starting materials,a visible-light-mediated one-pot multicomponent reaction was conducted under mild conditions to yield secondary amines efficiently.The experiment features cost-effective and readily available reagents,simple operation,and mild reaction conditions,alongside incorporating principles of green chemistry and organic synthesis methodology.Suitable for undergraduate laboratory teaching,it provides students with practical skills while deepening their comprehension of topics such as photochemical reactions,one-pot tandem reactions,and free radical processes.This experiment bridges the gap between cutting-edge research and talent cultivation,enhancing students'abilities in scientific research,innovation,and practical application.关键词
光化学/仲胺/一锅法串联反应/自由基反应Key words
Photochemistry/Secondary amines/One-pot tandem reaction/Free radical reaction分类
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姚震,林冰,田又平,李涛,张文会,刘雄伟,杨武德..可见光介导多组分一锅法合成仲胺化合物及其机理探究[J].大学化学,2024,39(5):201-208,8.基金项目
中药学(民族药学)国家级实验教学示范中心(贵州中医药大学)本科实践教学质量与教学改革工程项目(示范中心教改合字(2023)04号) （民族药学）
