风湿病与关节炎2024，Vol.13Issue(6)：21-25,5.DOI:10.3969/j.issn.2095-4174.2024.06.005
D-二聚体/纤维蛋白原比值、白蛋白/纤维蛋白原比值与全身型幼年特发性关节炎合并巨噬细胞活化综合征的相关性分析
Correlation Analysis Between D-dimer/fibrinogen Ratio,Albumin/fibrinogen Ratio and Systemic Juvenile Idiopathic Arthritis with Macrophage Activation Syndrome
摘要
Abstract
Objective:To explore the correlation between D-dimer/fibrinogen ratio(DFR),albumin/fibrinogen ratio(AFR)and systemic juvenile idiopathic arthritis(sJIA)with macrophage activation syndrome(MAS).Methods:Sixty-eight newly diagnosed sJIA patients at Henan Children's Hospital from January 2017 to June 2022 were selected as the sJIA group,and 32 sJIA patients combined with MAS were selected as the MAS group.Collect clinical manifestations and laboratory indicators within 24 hours of diagnosis of sJIA and MAS in pediatric patients and compare them.The correlation between DFR,AFR and laboratory indicators was analyzed using Spearman correlation analysis.The value of DFR and AFR in the diagnosis of sJIA combined with MAS was evaluated by drawing receiver operating characteristic curves(ROCs).Results:① The levels of fibrinogen and serum albumin in the MAS group were significantly lower than those in the sJIA group,while D-dimer,DFR,and AFR were significantly higher than those in the sJIA group,with statistical significance(P＜0.01).② DFR and AFR were positively correlated with aspartate aminotransferase,alanine aminotransferase,lactate dehydrogenase,triglycerides,and serum ferritin,while negatively correlated with C-reactive protein,erythrocyte sedimentation rate,white blood cell count,and platelet count,with statistically significant differences(P＜0.05).③Multiple linear regression analysis showed an independent correlation(P＜0.05)between the diagnosis of AFR and sJIA combined with MAS.④According to the ROC curve,the optimal cutoff values for DFR and AFR in diagnosing sJIA combined with MAS were 0.86 and 11.16,respectively(sensitivity 92.6%,specificity 85.7%,AUC=0.956;sensitivity 97.1%,specificity 78.6%,AUC=0.946).The combined diagnostic sensitivity of DFR and AFR was 94.1%(specificity 92.9%,AUC=0.98).Conclusion:DFR and AFR are related to the activity of sJIA combined with MAS,and their combined detection is helpful for the early diagnosis of MAS.关键词
全身型幼年特发性关节炎/巨噬细胞活化综合征/D-二聚体/纤维蛋白原比值/白蛋白/纤维蛋白原比值Key words
systemic juvenile idiopathic arthritis/macrophage activation syndrome/DFR/AFR引用本文复制引用
刘平,江春亚,王向丽,靳云凤,魏磊,陈莹华,李迪,刘翠华..D-二聚体/纤维蛋白原比值、白蛋白/纤维蛋白原比值与全身型幼年特发性关节炎合并巨噬细胞活化综合征的相关性分析[J].风湿病与关节炎,2024,13(6):21-25,5.基金项目
河南省医学科技攻关项目(LHGJ20210623) （LHGJ20210623）
