赣南医学院学报2024，Vol.44Issue(5)：464-469,6.DOI:10.3969/j.issn.1001-5779.2024.05.004
AMPA受体亚基GluA4在脑功能和神经精神疾病中的作用
The role of AMPAR subunit GluA4 in brain function and neuropsychiatric diseases
摘要
Abstract
The expression of AMPA receptor(α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor,AMPAR)subunit GluA4 is developmentally regulated in different brain regions and different types of cells,and the GluA4 homotetramer receptors characterized by high Ca2+permeability and sub-millisecond gating dynamics underlie fast synaptic responses and high-fidelity neurotransmission.They play an important role in neural circuit formation and neural information transmission.More and more studies have shown that abnormal GluA4 expression may disrupt the discharge rhythm of neural circuits,hinder neural information transmission,and impair learning and memory,leading to the occurrence of neuropsychiatric diseases such as epilepsy and Alzheimer's disease.This article reviews the current research on the role of GluA4 in normal physiological functions of the brain and neuropsychiatric diseases such as depression,Alzheimer's disease,schizophrenia,and epilepsy.关键词
AMPA受体/GluA4/突触可塑性/神经精神疾病Key words
AMPA receptor/GluA4/Synaptic plasticity/Neuropsychiatric diseases分类
医药卫生引用本文复制引用
张珺,夏宇杰,杨咏琪,王丽媛,何悦,刘艳玲..AMPA受体亚基GluA4在脑功能和神经精神疾病中的作用[J].赣南医学院学报,2024,44(5):464-469,6.基金项目
国家自然科学基金项目(31960172) （31960172）
