临床与病理杂志2024，Vol.44Issue(3)：488-493,6.DOI:10.11817/j.issn.2095-6959.2024.240015
伊马替尼靶向治疗后胃肠间质瘤伴横纹肌肉瘤分化1例及文献复习
Gastrointestinal stromal tumor with rhabdomyosarcoma differentiation after imatinib targeted therapy:A case report and literature review
袁亦姝 1冯智超 2谭娟 1程文静 1刘杨1
作者信息
- 1. 中南大学湘雅三医院病理科,长沙 410013
- 2. 中南大学湘雅三医院放射科,长沙 410013
- 折叠
摘要
Abstract
Gastrointestinal stromal tumor(GIST)is the most common mesenchymal tumor of the digestive tract.With the application of imatinib,the efficacy of treatment for advanced GIST has significantly improved.Although most patients benefit from imatinib therapy,some patients develop secondary resistance.In this particular case,a GIST patient developed resistance and tumor progression after 15 months of imatinib treatment.Microscopic examination showed significant polymorphism in some tumor cells and immunohistochemistry indicated rhabdomyoblastic differentiation.No secondary mutations in the c-Kit and PDGFRA genes were found in the progressive lesions.Due to the rarity of rhabdomyosarcoma dedifferentiation in GIST,this case report will aid in the diagnosis of GIST following imatinib treatment,helping to avoid misdiagnosis and missed diagnosis.关键词
胃肠间质瘤/伊马替尼/横纹肌肉瘤分化Key words
gastrointestinal stromal tumor/imatinib/rhabdomyosarcoma differentiation引用本文复制引用
袁亦姝,冯智超,谭娟,程文静,刘杨..伊马替尼靶向治疗后胃肠间质瘤伴横纹肌肉瘤分化1例及文献复习[J].临床与病理杂志,2024,44(3):488-493,6.
