保健医学研究与实践2023，Vol.20Issue(z2)：252-257,6.DOI:10.11986/j.issn.1673-873X.2023.S2.71
远程缺血适应的研究进展
New directions in myocardial protection:the comprehensive remote ischemic conditioning
刘启 1韩珂1
作者信息
- 1. 滨州医学院烟台附属医院心脏大血管外科,山东 烟台 264000
- 折叠
摘要
Abstract
Remote ischemic conditioning(RIC)is the reversible ischemia-reperfusion of the vascular bed,tissue or organ to reduce the damage of the remote target tissue/organ after reperfusion.A recent large multicenter trial(CONDI-2/ERIC-PPCI)demonstrated no significant benefit for major clinical endpoints such as myocardial infarction size and cardiac death,and further studies are needed to a-dapt to current clinical settings.Comprehensive remote ischemic adaptation is a result of the combined application of remote ischemia in the treatment of myocardial infarction.Breakthroughs have been made in limiting the size of myocardial infarction and in preventing heart failure and ventricular remodeling after infarction.In this paper,the latest protective mechanisms,signal transduction pathways and carriers of RIC are described,and based on this,the additional myocardial protection benefits obtained by RIC under the condition that the same protective mechanisms are superimposed and different mechanisms are complementary at different treatment times are discussed,aiming to provide clinical ideas through the latest research progress of RIC.To explore individualized myocardial protection model suitable for patients.关键词
远程缺血适应/缺血/再灌注损伤/缺血性心脏病/心脏重塑/心肌梗死Key words
Remote ischemic conditioning/Ischemia reperfusion injury/Ischemic heart disease/Cardiac remodeling/Myocardial infarc-tion分类
医药卫生引用本文复制引用
刘启,韩珂..远程缺血适应的研究进展[J].保健医学研究与实践,2023,20(z2):252-257,6.
