广州医药2024，Vol.55Issue(5)：448-456,462,10.DOI:10.3969/j.issn.1000-8535.2024.05.001
仿生心肌微环境介导的材料生物学研究
Materiobiology research mediated by biomimetic myocardial microenvironment
摘要
Abstract
Myocardial infarction(MI),arising from coronary artery obstruction resulting in hypoxic necrosis of myocardium,remains high morbidity and mortality.Recent studies have revealed that constructing myocardial microenvironment bionically through tissue engineering methods can effectively ameliorate the microenvironment in the infarcted area and exert a crucial regulatory role in myocardial regeneration,which promotes myocardial regeneration to a certain extent and holds promise for the treatment of MI.However,the interaction between biomimetic myocardial microenvironment and host microenvironment,as well as the triggered biological effects and mechanisms are not clear,which directly affects the process and quality of myocardial repair.Therefore,it is urgent to clarify the interaction process and biological effects mediated by the biomimetic myocardial microenvironment during myocardial repair.This review systematically summarizes the construction strategies of biomimetic myocardial microenvironment and their mediated biological effects after implantation,including immunomodulatory effects,pro-vascular regenerative effects,and regenerative synergistic effects,which provides theoretical support for the biomimetic design and clinical application of novel cardiac patches.关键词
仿生/心肌微环境/心肌梗死/材料生物学Key words
biomimetic/myocardial microenvironment/myocardial infarction/materiobiology引用本文复制引用
丁成斌,邵子怡,曾钰婷,宋咏怡,章文俊,王乐禹..仿生心肌微环境介导的材料生物学研究[J].广州医药,2024,55(5):448-456,462,10.基金项目
国家自然科学基金(32071355) （32071355）
广东省基础与应用基础研究基金(2022A1515011888) （2022A1515011888）
