广州医药2024，Vol.55Issue(5)：457-462,6.DOI:10.3969/j.issn.1000-8535.2024.05.002
MDSCs调控新生儿免疫应答机制及其临床意义
Mechanism and clinical significance of MDSCs regulation of neonatal immune response
摘要
Abstract
The developmental stage of the immune system during the neonatal period is crucial for maintaining neonatal health,characterized by unique immunoregulatory mechanisms.In recent years,increasing attention has been drawn to the role of myeloid-derived suppressor cells(MDSCs)in neonatal immune regulation.MDSCs represents a heterogeneous population of cells with potent immunosuppressive functions,capable of modulating immune responses through various mechanisms.The regulatory role of MDSCs in neonates is vital for preventing excessive immune reactions and promoting immune tolerance,thereby aiding in the prevention of neonatal inflammatory diseases and positively influencing subsequent health outcomes.Analysis of recent research literature reveals multiple mechanisms through which MDSCs contribute to neonatal immune regulation,including protective effects under specific pathological conditions,interactions with neonatal inflammatory responses,and potential impacts on long-term immune development.Therefore,a comprehensive understanding of the role of MDSCs in neonatal immunity not only helps elucidate their intricate regulatory mechanisms but also provides novel insights for developing strategies for the prevention and treatment of neonatal inflammatory diseases.关键词
新生儿/髓源性抑制细胞/免疫调节Key words
newborn/myeloid-derived suppressor cells(MDSCs)/immune regulation引用本文复制引用
徐凝,王丽娜,刘国成,刘雨丰..MDSCs调控新生儿免疫应答机制及其临床意义[J].广州医药,2024,55(5):457-462,6.基金项目
国家自然科学基金面上项目(8217060280) （8217060280）
广州市校(院)企联合资助项目(SL2024A03J01319) （院）
广东省基础与应用基础研究专题(优秀博士"续航"项目)(SL2024A04J00240) （优秀博士"续航"项目）
