广州医药2024，Vol.55Issue(5)：513-518,6.DOI:10.3969/j.issn.1000-8535.2024.05.009
振幅整合脑电图联合头颅磁共振预测早产儿矫正12月龄时神经发育的价值
Predictive value of aEEG combined with cranial MRI on neurodevelopment for preterm infants at corrected age of 12 months
摘要
Abstract
Objective To evaluate the predictive value of amplitude-integrated electroencephalogram combined with cranial magnetic resonance on neurodevelopment for preterm infants at corrected age of 12 months.Methods A total of 110 preterm infants were selected as study subjects,and Gesell developmental scale was used to evaluate developmental quotient(DQ)at corrected age of 12 months.According to DQ,they were divided into normal Gesell group(DQ≥85,n=83)and abnormal Gesell group(DQ＜85,n=27).Clinical data of preterm infants and their mothers were collected,and the differences of amplitude-integrated electroencephalogram and cranial MRI(cMRI)were compared between two groups.Results There was no significant difference in baseline data between two groups(P＞0.05).Compared with the normal Gesell group,the biparirtal width(BPW)in the abnormal Gesell group was decreased(70.68±5.32mmvs66.54±3.69mm),the immaturity rate of sleep-wake cycle(SWC)(20.48%vs 85.19%),the abnormal rate of aEEG(30.12%vs 70.37%),and(IHD)(2.95±0.83mm vs 3.56±0.72mm)were increased(P＜0.05).The results of Pearson correlation analysis showed that DQ was negatively correlated with IHD,and DQ was positively correlated with BPW(r=-0.361、0.598,P＜0.05).Binary Logistic regression analysis showed that increased BPW was an independent protective factor for abnormal Gesell(P＜0.05),and increased IHD,immature SWC and abnormal aEEG were independent risk factors for abnormal Gesell(P＜0.05).Conclusions Abnormal aEEG within 72h after birth and abnormal cMRI at corrected age of 37 weeks may lead to adverse neurodevelopmental outcomes at corrected age of 12 months.关键词
早产儿/神经发育/振幅整合脑电图/头颅磁共振成像Key words
preterm infant/neurodevelopment/amplitude-integrated electroencephalogram/cranial magnetic resonance imaging引用本文复制引用
黄丹,蓝国海,刘祥晖,覃荣苗,梁秋艳,夏文强..振幅整合脑电图联合头颅磁共振预测早产儿矫正12月龄时神经发育的价值[J].广州医药,2024,55(5):513-518,6.基金项目
广西壮族自治区卫生健康委员会自筹经费科研课题(Z20211054) （Z20211054）
