海南师范大学学报（自然科学版）2024，Vol.37Issue(2)：179-188,10.DOI:10.12051/j.issn.1674-4942.2024.02.007
海藻酸盐复合凝胶在骨组织工程中的研究进展
Research Progress of Alginate Composite Gel in Bone Tissue Engineering
摘要
Abstract
Bone tissue engineering(BTE)scaffolds are artificial scaffolds developed for the purpose of repairing the defect of bone and restoring its function.Alginate is the most abundant marine biopolymers in the world,and its application in bone tissue engineering materials has been widely reported.Although alginate as bone tissue scaffold material has excellent biocompatibility,good biodegradability and no immunogenicity,it still has some disadvantages such as weak mechanical strength,lack of cell-specific binding sites,and easy destruction of scaffold structure in physiological environment,which seriously limits its application in bone tissue engineering.So far,researchers have developed several types of alginate com-posite scaffold materials.Therefore,the alginate composite biomaterial may have high application value in bone tissue re-pair and regeneration.For this reason,this article mainly focuses on the application of alginate composite scaffold materials in bone tissue engineering to give a brief overview.关键词
海藻酸盐/天然高分子/复合凝胶支架/骨材料/骨组织工程Key words
alginate/natural polymer/composite hydrogel scaffold/bone materials/bone tissue engineering分类
化学化工引用本文复制引用
吴婷,李东泽,孙秀英,陈秀琼,颜慧琼,林强..海藻酸盐复合凝胶在骨组织工程中的研究进展[J].海南师范大学学报（自然科学版）,2024,37(2):179-188,10.基金项目
国家自然科学基金项目(51963009) （51963009）
海南省重点研发项目(ZDYF2019018) （ZDYF2019018）
海南省自然科学基金项目(220MS035) （220MS035）
海南省研究生创新科研课题资助项目(Hys2020-309) （Hys2020-309）
