线粒体功能异常在子宫内膜异位症相关不孕中的研究进展OA北大核心CSTPCDMEDLINE

Endometriosis(EMT),a common benign gynecological disease,is a leading cause of infertility in women.EMT affects female fertility in various aspects.However,the underlying mechanisms have not been fully elucidated.Mitochondria are known as the"powerhouse"of a cell.They play pivotal roles in the physiological processes of cellular energy metabolism,calcium homeostasis,oxidative stress,autophagy,the regulation of cell cycle,and cell death,and are involved in the pathophysiology of many diseases.Cellular mitochondria are highly dynamic,continuously undergoing cyclic fission and fusion to meet the demands of cellular activities.Balanced mitochondrial dynamics are critical for maintaining normal reproductive function in women.In addition,mitochondria are the major source of reactive oxygen species(ROS).Cell damage,cell death,and fibrosis mediated by the imbalance in the oxidative-antioxidant system in EMT patients lead to decreased oocyte quality and ovarian reserve.Currently,the treatment of EMT-associated infertility remains a challenging and controversial topic.We herein reviewed the latest findings on the role of mitochondrial dysfunction in EMT-associated infertility and the potential therapeutic targets.