四川大学学报（医学版）2024，Vol.55Issue(3)：574-579,6.DOI:10.12182/20240560504
宫腔灌注粒细胞集落刺激因子改善薄型子宫内膜患者内膜及血流参数的前瞻性临床对照试验
Effect of Intrauterine Perfusion of Granulocyte Colony-Stimulating Factor on Endometrium and Blood Flow Parameters in Patients With Thin Endometrium:A Prospective Controlled Clinical Trial
摘要
Abstract
Objective To investigate the effects of intrauterine perfusion with granulocyte colony-stimulating factor(G-CSF)on the endometrial thickness,volume,and blood flow parameters of patients with thin endometrium and their clinical outcomes.Methods We designed a prospective non-randomized synchronous controlled trial and recruited patients with thin endometrium who underwent frozen-thawed embryo transfer(FET)at Mianyang Central Hospital between September 1,2021 and September 1,2023.They were divided into two groups,an experimental group of patients who received the experimental treatment of intrauterine perfusion with G-CSF and a control group of patients who did not receive the experimental treatment.The general data and the clinical outcomes of the two groups were analyzed and compared.The endometrial thickness,volume and blood flow parameters of patients in the experimental group before and after intrauterine perfusion with G-CSF were analyzed.Results The clinical data of 83 patients were included in the study.The experimental group included 51 cases,while the control group included 31 cases.There were no significant differences in the baseline data between the two groups.The clinical pregnancy rate of the experimental group(56.86% )was higher than that of the control group(50.00% )and the rate of spontaneous abortion in the experimental group(27.59% )was lower than that in the control group(37.50% ),but the differences were not statistically significant(P>0.05).In the experimental group,the postperfusion endometrial thickness([0.67±0.1]cm)was greater than the preperfusion endometrial thickness([0.59±0.09]cm),the postperfusion([1.84±0.81]cm3)was greater than the preperfusion endometrial volume([1.54±0.69]cm3),and the postperfusion vascularization flow index(VFI)(1.97±2.82)was greater than the preperfusion VFI(0.99±1.04),with all the differences being statistically significant(P<0.05).Conclusion Intrauterine perfusion with G-CSF can enhance the endometrial thickness,volume,and some blood flow parameters in patients with thin endometrium.关键词
宫腔灌注/粒细胞集落刺激因子/薄型子宫内膜/内膜容受性Key words
Intrauterine perfusion/Granulocyte colony-stimulating factor/Thin endometrium/Endometrial receptivity引用本文复制引用
徐少蓉,马琴芹,雍佳嘉,赖婷,苏莲,向鸿,马黔红,张耀,安银华,何玮,马瑛,李俊林,李丹,路巍..宫腔灌注粒细胞集落刺激因子改善薄型子宫内膜患者内膜及血流参数的前瞻性临床对照试验[J].四川大学学报（医学版）,2024,55(3):574-579,6.基金项目
四川大学校级横向课题(No.22H0602)资助 （No.22H0602）
