三参通脉合剂通过上调microRNA-146a改善大鼠心肌细胞H9C2的氧化损伤OA北大核心CSTPCDMEDLINE
Sanshentongmai Mixture Improves Oxidative Damage in Rat Cardiomyocytes H9C2 via Upregulation of microRNA-146a
目的 探讨三参通脉(Sanshentongmai,SSTM)合剂调节微小RNA-146a(microRNA-146a)对大鼠心肌细胞H9C2氧化损伤的影响及作用机制.方法 体外培养大鼠心肌细胞H9C2,过氧化氢(H2O2)作为氧化剂制作H9C2氧化应激模型.通过三参通脉干预,观察H2O2诱导的H9C2细胞氧化损伤的变化以及microRNA-146a的表达,探讨三参通脉对H9C2的保护作用及其作用机制.将体外培养的H9C2分为空白组、H2O2氧化损…查看全部>>
Objective To investigate the effect of Sanshentongmai(SSTM)mixture on the regulation of oxidative damage to rat cardiomyocytes(H9C2)through microRNA-146a and its mechanism.Methods H9C2 were cultured in vitro,H2O2 was used as an oxidant to create an oxidative damage model in H9C2 cells.SSTM intervention was administered to the H9C2 cells.Then,the changes in H2O2-induced oxidative damage in H9C2 cells and the expression of microRNA-146a were observed to explor…查看全部>>
李然;王振裕;王燕丽;滕菲
首都医科大学附属北京中医医院干部保健科 (北京 100010)首都医科大学附属北京中医医院干部保健科 (北京 100010)首都医科大学附属北京中医医院干部保健科 (北京 100010)首都医科大学附属北京中医医院干部保健科 (北京 100010)
大鼠心肌细胞H9C2三参通脉合剂氧化损伤微小RNA-146a
H9C2 cell lineSanshentongmai mixtureOxidative damagemicroRNA-146a
《四川大学学报（医学版）》 2024 (3)
630-634,5
国家自然科学基金(No.8150140342)资助
评论