四川大学学报（医学版）2024，Vol.55Issue(3)：777-782,6.DOI:10.12182/20240560607
miRNA通过靶向骨保护素参与多种疾病的发病机制
miRNA Is Involved in the Pathogenesis of Multiple Diseases by Targeting Osteoprotegerin
摘要
Abstract
As a member of the tumor necrosis factor receptor family,osteoprotegerin(OPG)is highly expressed in adults in the lung,heart,kidney,liver,spleen,thymus,prostate,ovary,small intestines,thyroid gland,lymph nodes,trachea,adrenal gland,the testis,and bone marrow.Together with the receptor activator of nuclear factor-κB(RANK)and the receptor activator of nuclear factor-κB ligand(RANKL),it forms the RANK/RANKL/OPG pathway,which plays an important role in the molecular mechanism of the development of various diseases.MicroRNAs(miRNAs)are a class of endogenous non-coding RNAs performing regulatory functions in eukaryotes,with a size of about 20-25 nucleotides.miRNA genes are transcribed into primary transcripts by RNA polymerase,bind to RNA-induced silencing complexes,identify target mRNAs through complementary base pairing,with a single miRNA being capable of targeting hundreds of mRNAs,and influence the expression of many genes through pathways involved in functional interactions.In recent years,a large number of studies have been done to explore the mechanism of action of miRNA in diseases through miRNA isolation,miRNA quantification,miRNA spectrum analysis,miRNA target detection,in vitro and in vivo regulation of miRNA levels,and other technologies.It was found that miRNA can play a key role in the pathogenesis of osteoporosis,rheumatoid arthritis,and other diseases by targeting OPG.The purpose of this review is to explore the interaction between miRNA and OPG in various diseases,and to propose new ideas for studying the mechanism of action of OPG in diseases.关键词
骨保护素/微小RNA/骨质疏松/类风湿性关节炎/动脉粥样硬化/肿瘤/综述Key words
Osteoprotegerin/microRNA/Osteoporosis/Rheumatoid arthritis/Atherosclerosis/Tumor/Review引用本文复制引用
周铎,杨德琴..miRNA通过靶向骨保护素参与多种疾病的发病机制[J].四川大学学报（医学版）,2024,55(3):777-782,6.基金项目
国家自然科学基金项目(No.32270888、No.31970783)资助 （No.32270888、No.31970783）
