四川大学学报（医学版）2024，Vol.55Issue(3)：783-792,10.DOI:10.12182/20240560302
α-酮戊二酸在代谢综合征中的研究进展
Latest Findings on the Role of α-Ketoglutarate in Metabolic Syndrome
摘要
Abstract
Alpha-ketoglutarate(α-KG),an endogenous intermediate of the tricarboxylic acid cycle,is involved in a variety of cellular metabolic pathways.It serves as an energy donor,a precursor of amino acid biosynthesis,and an epigenetic regulator.α-KG plays physiological functions in immune regulation,oxidative stress,and anti-aging as well.In recent years,it has been reported that the level of α-KG in the body is closely associated with metabolic syndrome,including obesity,hyperglycemia,and other pathological factors.Exogenous supplementation of α-KG improves obesity,blood glucose levels,and cardiovascular disease risks associated with metabolic syndrome.Furthermore,α-KG regulates the common pathological mechanisms of metabolic syndrome,suggesting the potential application prospect of α-KG in metabolic syndrome.In order to provide a theoretical basis for further exploration of the application of α-KG in metabolic syndrome,we focused on α-KG and metabolic syndrome in this article and summarized the latest research progress in the role of α-KG in improving the pathological condition and disease progression of metabolic syndrome.For the next step,researchers may focus on the co-pathogenesis of metabolic syndrome and investigate whether α-KG can be used to achieve the therapeutic goal of"homotherapy for heteropathy"in the treatment of metabolic syndrome.关键词
α-酮戊二酸/代谢综合征/肥胖/高血糖/免疫调控/代谢/综述Key words
Alpha-ketoglutarate/Metabolic syndrome/Obesity/Hyperglycemia/Immunoregulation/Metabolism/Review引用本文复制引用
李雨含,王瑗,袁泉..α-酮戊二酸在代谢综合征中的研究进展[J].四川大学学报（医学版）,2024,55(3):783-792,10.基金项目
国家自然科学基金项目(No.82201030)和四川省自然科学基金项目(No.2022NSFSC1334)资助 （No.82201030）
