抑郁对帕金森病患者生活质量的影响分析OACSTPCD

Objective To explore the effect of depression in Parkinson's disease(PD)on the quality of life of patients.Methods The patients in this study were from the outpatient department and inpatients of PD specialty of Nanjing Brain Hospital from May 1,2022 to December 31,2022.The 199 patients were screened with Hamilton Depression Scale(HAMD-17)and 39 PD Quality of Life Questionnaire(PDQ-39).According to the HAMD-17 score,HAMD-17<14 was divided into PD group,and HAMD-17≥14 was divided into PD combined with depression group.The differences between the two groups in age,age of onset,course of disease,HAMD-17 score,PDQ-39 score,UPDRS-Ⅰ,UPDRS-Ⅱ,UPDRS-Ⅲwere compared,and the relationship between the PDQ-39 sub-dimension and HAMD-17 and the average score of the PDQ-39 sub-dimension of the two groups were further analyzed.Finally,the possible factors affecting the quality of life of patients were analyzed.Results The correlation analysis of each subdimension of HAMD-17 and PDQ-39 showed that except for physical discomfort,the other seven dimensions of PDQ-39 were positively correlated with HAMD-17 score,the differences were statistically significant(all P<0.05).Multiple linear regression analysis showed that in addition to HAMD-17,the influencing factors of quality of life were also associated with UPDRS-Ⅱ(activities of daily living).Conclusion PD complicated with depression is common,depressive symptoms can significantly affect the quality of life of patients.