农药学学报2024，Vol.26Issue(3)：559-569,11.DOI:10.16801/j.issn.1008-7303.2024.0036
中空介孔二氧化硅负载戊唑醇纳米缓释颗粒的制备及生物活性
Preparation and biological activity of hollow mesoporous silica loaded tebuconazole nano sustained release granules
摘要
Abstract
In this study,tebuconazole@hollow mesoporous nano silica(Teb@HMS)sustained release granules were prepared.The morphology,structure,and properties were characterized by scanning electron microscopy(SEM),transmission electron microscopy(TEM),Fourier transform infrared spectroscopy(FTIR),specific surface area analyzer(BET),thermogravimetric analyzer(TGA),and other instruments.The release behavior of tebuconazole in sustained-release granules was investigated by high-performance liquid chromatography(HPLC)analysis.The inhibitory activity of Teb@HMS on Rhizoctonia solani was determined by mycelial growth inhibition,potted experiments,and field control efficacy experiments.The safety of Teb@HMS was evaluated through rice seed germination experiments and zebrafish experiments.It was shown that the prepared drug-loaded nanosilica particles exhibited a regular hollow mesoporous structure.The drug loading rate for tebuconazole was 52.02%and the sustained release time was up to 400 hours.Meanwhile,Teb@HMS reduced the toxicity of tebuconazole to non-target rice seeds and zebrafish.The antifungal activity of Teb@HMS was significantly better than the positive control tebuconazole.On the 18th day of pot and field trails,Teb@HMS protection efficacy reached 61.79%and 70.42%,respectively.This study provides technical support and theoretical guidance for the application of hollow mesoporous nano silica sustained-release granules in pesticide reduction and green and sustainable prevention and control of plant diseases.关键词
中空介孔纳米二氧化硅/戊唑醇/缓释颗粒/水稻纹枯病/立枯丝核菌/安全性评价/生物活性Key words
hollow mesoporous nano silica/tebuconazole/sustained release granules/rice sheath blight/Rhizoctonia solani/safety evaluation/biological activity分类
化学化工引用本文复制引用
桂阔,周瑞,惠托平,刘夷宁,张欣茹,李文奎,雷鹏,高艳清,马志卿..中空介孔二氧化硅负载戊唑醇纳米缓释颗粒的制备及生物活性[J].农药学学报,2024,26(3):559-569,11.基金项目
国家重点研发计划项目(2023YFD1701200) （2023YFD1701200）
陕西省重点研发计划项目(2024NC-YBXM-255). Supported by National Key Research and Development Program of China(No.2023YFD1701200),Key Research and Development Program of Shaanxi Province(No.2024NC-YBXM-255). （2024NC-YBXM-255）
