农药学学报2024，Vol.26Issue(3)：427-439,13.DOI:10.16801/j.issn.1008-7303.2024.0047
手性农药对映选择活性及机制研究进展
Advances on enantioselective activity and it's mechanism of chiral pesticides
摘要
Abstract
Chiral pesticide enantiomers often show different bioactivity in controlling harmful organisms.It is of great significance to pay attention to the selective activity of chiral pesticide enantiomers to promote the reduction and efficiency of pesticides and to develop green agriculture.In this paper,according to the research status of enantioselective activity of chiral pesticides,the research on enantioselective activity mechanism is summarized into two aspects:On the one hand,computer simulation technology is used to analyze the binding ability between enantiomers and active sites of target molecules,and a few of them have also carried out biological experiments;on the other hand,the study explored the differences in absorption,transportation and metabolism of chiral pesticide enantiomers in biological systems by means of radioisotope tracing and quantitative analysis of metabolites.This paper aims to provide reference for the identification of highly active activity chiral pesticide monomers and the development of new green pesticides with high efficiency and low risk.关键词
手性农药/对映体/立体选择性/生物活性/机制Key words
chiral pesticides/enantiomers/enantioselective activity/bioactivity/mechanism分类
化学工程引用本文复制引用
朱俊琪,李远富,毛凯凯,谢发扬,谭辉华,赵锋..手性农药对映选择活性及机制研究进展[J].农药学学报,2024,26(3):427-439,13.基金项目
国家自然科学基金-青年科学基金项目(32302398) （32302398）
广西科技计划项目-青年创新人才科研专项(2022AC21245). Supported by National Natural Science Foundation-Youth Science Fund Project(No.32302398),Science and Technology Planning Project of Guangxi-Fund Project for Young Innovative Talents(No.2022AC21245). （2022AC21245）
