农药学学报2024，Vol.26Issue(3)：462-471,10.DOI:10.16801/j.issn.1008-7303.2024.0039
桧木醇酯类衍生物的设计合成及抑菌活性
Design,synthesis and antifungal activity of hinokitiol ester derivatives
摘要
Abstract
As a continuous research on structure derivation and activity of natural monoterpenoid hinokitiol,15 novel hinokitol carboxylic acid esters(3)and 20 hinokitol sulfonate esters(isomers 5 and 6)were designed and synthesized from hinokitiol as a lead compound.The results of fungicidal activity showed that most of the target compounds at 50 μg/mL exhibited good fungicidal activity against Valsa mali,Rhizoctonia solani,Botrytis cinerea,and Colletotrichum orbiculare.The EC50 values of 3a,3f,3g,3o against R.solani were 0.96,1.05,1.29 and 1.88 μg/mL,respectively,the EC50 values of 3a,3e and 3j were 3.60,3.28 and 3.48 μg/mL against V.mali,and the EC50 values of 3d,3f and 3g were 0.77,0.51 and 0.67 μg/mL against C.orbiculare,respectively,which were superior to hinokitol.In general,the fungicidal activity of carboxylate derivatives was significantly better than that of sulfonate derivatives.The position isomers of sulfonate derivatives possessed different fungicidal activities,among which the compound with configuration 1 has better activities.关键词
桧木醇/抑菌活性/苹果树腐烂病菌/水稻纹枯病菌/黄瓜炭疽病菌Key words
hinokitiol/antifungal activity/Valsa mali/Rhizoctonia solani/Colletotrichum orbiculare分类
化学化工引用本文复制引用
叶久辉,桂阔,殷妮,刘新,李璇,雷鹏,冯俊涛,马志卿,高艳清..桧木醇酯类衍生物的设计合成及抑菌活性[J].农药学学报,2024,26(3):462-471,10.基金项目
国家重点研发计划项目(2023YFD1701200) （2023YFD1701200）
陕西省重点研发计划项目(2024NC-YBXM-255) （2024NC-YBXM-255）
大学生创新创业训练计划项目(S202310712245). Supported by The National Key Research and Development Program of China(No.2023YFD1701200),Key Research and Development Program of Shaanxi Province(No.2024NC-YBXM-255),Undergraduate Training Program for Innovation and Entrepreneurship(No.S202310712245). （S202310712245）
