山东医药2024，Vol.64Issue(15)：9-12,4.DOI:10.3969/j.issn.1002-266X.2024.15.002
肝硬化患者血清高迁移率族蛋白B水平变化及其与肠黏膜通透性的相关性
Changes in levels of serum HMGB1 in patients with liver cirrhosis and its correlation with intestinal mucosal permeability
摘要
Abstract
Objective To observe the changes in levels of serum high-mobility group protein B1(HMGB1)level and intestinal mucosal permeability(IP)-related indicators[D-lactic acid(D-lac),diamine oxidase(DAO),and endotox-in(ET)]in patients with liver cirrhosis,and to analyze the correlations between the level of serum HMGB1 and IP-related indicators to clarify the relationship between the level of serum HMGB1 and the IP of patients.Methods Sixty-three pa-tients with liver cirrhosis were enrolled.According to the Child-Pugh score,the patients were divided into the CP-A group(n=16),CP-B group(n=32)and CP-C group(n=15);33 cases of healthy people who underwent physical examination in the same period were used as the control group.The serum levels of HMGB1,ET,DAO and D-lac were detected by ELI-SA.The correlation between serum HMGB1,IP-related indicators and Child-Pugh classification,and the correlation be-tween serum HMGB1 and IP-related indicators in patients with liver cirrhosis were analyzed.Results The levels of HMGB1,ET,DAO and D-lac in the CP-A,CP-B and CP-C groups were higher than those in the control group,the levels of HMGB1,D-lac and ET in the CP-C group were higher than those in the CP-A group,and the levels of HMGB1 and ET in the CP-B group were higher than those in the CP-A group(all P<0.05).Serum HMGB1 was positively correlated with IP-related indicators ET,DAO and D-lac(r=0.371,0.854,0.623,all P<0.05).The serum levels of HMGB1,ET,DAO and D-lac in patients with liver cirrhosis were positively correlated with Child-Pugh classification(r=0.356,0.272,0.301 and 0.382,respectively,all P<0.05).Conclusion The serum HMGB1 level in patients with liver cir-rhosis increases,and IP increases,and they change more significantly with the severity of the disease;there is a positive correlation between the serum HMGB1 level and the patients'IP.关键词
高迁移率族蛋白B1/肠黏膜通透性/D-乳酸/二胺氧化酶/内毒素/肝硬化Key words
high-mobility group protein B1/intestinal permeability/D-lactic acid/diamine oxidase/endotoxin/liver cirrhosis分类
医药卫生引用本文复制引用
谢娇娇,何燕芳,马燕花,郭才,郑兰兰..肝硬化患者血清高迁移率族蛋白B水平变化及其与肠黏膜通透性的相关性[J].山东医药,2024,64(15):9-12,4.基金项目
国家自然科学基金地区基金项目(81860821). （81860821）
