日用化学工业（中英文）2024，Vol.54Issue(6)：677-682,6.DOI:10.3969/j.issn.2097-2806.2024.06.008
Fe3O4纳米粒子的制备及载药释放性能研究
Preparation of Fe3O4 nanoparticles and its drug-loading and drug-release properties
高蓉 1石森林1
作者信息
- 1. 浙江中医药大学 药学院,浙江 杭州 310053
- 折叠
摘要
Abstract
Graphene oxide(GO)was obtained by the improved Hummers method.The GO/Fe3O4 composite,in which GO was combined with magnetic Fe3O4 nanoparticles,was prepared by co-precipitation method.The crystalline structure,microscopic morphology,magnetic properties and drug loading of the composite were analyzed.The results showed that:The GO/Fe3O4 composite had high crystallinity;GO doping improved the uniformity of Fe3O4 particles,and the grain size of GO/Fe3O4 composite was 13-15 nm.The GO/Fe3O4 composite exhibited superparamagnetic properties with a slight decrease in saturation magnetization.The drug-release properties were studied by using GO/Fe3O4 composite to load doxorubicin(DOX).The average encapsulation efficiency of GO/Fe3O4/DOX inclusion complex was 62.24％,which was quite high.The drug release showed pH dependence.When the pH was 7.4,the cumulative release rate reached 73.3％in 75 h.The cellular uptake test showed that the GO/Fe3O4 carrier had certain targeting properties and could be used as a good new drug carrier.关键词
氧化石墨烯/Fe3O4/磁性材料/共沉淀法/阿霉素/药物载体Key words
graphene oxide/Fe3O4/magnetic material/co-precipitation method/doxorubicin/drug carrier分类
化学化工引用本文复制引用
高蓉,石森林..Fe3O4纳米粒子的制备及载药释放性能研究[J].日用化学工业（中英文）,2024,54(6):677-682,6.
