日用化学工业（中英文）2024，Vol.54Issue(6)：718-726,9.DOI:10.3969/j.issn.2097-2806.2024.06.013
虚拟筛选技术在黑色素生成抑制剂研发中的应用
Application of virtual screening technology in the development of melanin generation inhibitors
摘要
Abstract
With the development of economy and society,great business opportunities have emerged in the skin whitening and anti-spot industry.Melanin content and its distribution are considered to be important factors affecting skin color.Tyrosinase(TYR)is a key rate-limiting enzyme in the regulation of melanin content.Microphthalmia-associated transcription factor(MITF)is a major regulator of melanocytes and plays a key role in the differentiation and proliferation of melanocytes.A large number of studies have shown that by reducing the activity or stability of TYR,or interfering with the normal transcription of MITF,various skin problems caused by abnormal melanin production can be prevented or alleviated.Virtual screening has the advantages of low cost and high efficiency.This technology has a good application prospect in screening melanin synthesis inhibitors.In this paper,the synthesis and regulation of melanin were summarized,and the application progress of virtual screening technology in the development of melanin production inhibitors was reviewed,which provided a reference for exploring the lead compounds of melanin production inhibitors.关键词
黑色素抑制剂/酪氨酸酶/小眼畸形转录因子/虚拟筛选Key words
melanin inhibitors/tyrosinase/microphthalmia-associated transcription factor/virtual screening分类
化学化工引用本文复制引用
胡金金,刘智禹,陈小娥,陈贝..虚拟筛选技术在黑色素生成抑制剂研发中的应用[J].日用化学工业（中英文）,2024,54(6):718-726,9.基金项目
福建省水产研究所科技引领专项(2022KJYL04) （2022KJYL04）
