组蛋白修饰对胚胎干细胞分化过程的调控机制OACSTPCD

In this paper,human embryonic stem cell line and its differentiated neural stem cell line are selected as the objects to study the regulatory effect of histone modifications on the differentiation of embryonic stem cells.The distribution patterns of 8 histone modifications and functional clusters of histone modifications are obtained in the flanking regions of transcriptional initiation sites of the differentially expressed genes in the two cell lines.The results show that in the two cell lines,the distribution patterns of 8 histone modification profiles are consistent and show two distribution types;The functional clusters compose of H3K27ac,H3K4me3 and H3K9ac are conservative,while the functional clusters compose of H3K27me3,H3K36me3 and H3K79me1 and the functional clusters composed of H3K9me3 and H3K27me3 disappear during the differentiation of embryonic stem cells into neural stem cells.This paper reveals the partial regulatory mechanism of histone modifications on the differentiation of embryonic stem cell lines into neural stem cell lines and provids some important theoretical basis for the study of molecular regulatory mechanism of this differentiation process.