牡荆素鼠李糖苷通过EGFR抑制酒精引起的胃上皮细胞焦亡OACSTPCD
Pectin rhamnoside inhibits alcohol-induced gastric epithelial cell pyroptosis through EGFR
目的 探讨牡荆素鼠李糖苷(Vitexin-2"-o-rhamnoside,RHV)对酒精所致胃上皮细胞(human normal gastric epithelial cells,GES-1)焦亡是否有改善作用及其作用机制.方法 GES-1细胞分别用不同浓度(0,200,400,600,800,1 000 mmol/L)酒精干预,检测细胞存活率、焦亡相关蛋白的表达、乳酸脱氢酶(LDH)的释放量,筛选引起细胞焦亡的最佳干预浓度.GES-1细胞分别用…查看全部>>
Objective To clarify the improvement effect of Vitexin-2"-o-rhamnoside(RHV)on alcohol-induced gastric epithelial cell pyroptosis and its mechanism.Methods GES-1 cells were intervened with different concentrations of alcohol(0,200,400,600,800,1 000 mmol/L),and then the cell viability,the expressions of pyroptosis-related proteins and the lactate dehydrogenase(LDH)release were detected to screen the optimal intervention concentration for inducing the cell apop…查看全部>>
李姿墨;韩倩;原素梅;张晓延
山西医科大学公共卫生学院营养与食品卫生教研室,太原 030001||山西医科大学汾阳学院医学检验系山西医科大学公共卫生学院营养与食品卫生教研室,太原 030001||山西医科大学汾阳学院医学检验系||山西大同大学护理学院社区护理教研室山西医科大学汾阳学院医学检验系山西医科大学汾阳学院医学检验系
临床医学
酒精性胃炎牡荆素鼠李糖苷细胞焦亡网络药理学表皮生长因子受体
alcoholic gastritispectin rhamnosidecell pyroptosisnetwork pharmacologyepidermal growth factor receptor
《山西医科大学学报》 2024 (5)
568-579,12
吕梁市重点研发计划项目(2021SHFZ-2-98)
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