山西医科大学学报2024，Vol.55Issue(5)：644-649,6.DOI:10.13753/j.issn.1007-6611.2024.05.015
孟德尔随机化探索维生素B12缺乏性贫血和1型糖尿病风险的因果关系
Causal relationship between vitamin B12 deficiency anemia and risk of type 1 diabetes mellitus by Mendelian randomization analysis
摘要
Abstract
Objective To determine whether vitamin B12(VitB12)deficiency anemia is causally associated with type 1 diabetes(T1D)by Mendelian randomization analysis(MR).Methods From genome-wide association studies,the independent single nucleotide pol-ymorphisms(SNP)closely associated with T1D and VitB12 deficiency anemia were selected as instrumental variables.Inverse-variance weighting(IVW)was used for MR analysis,and additional weighted median(WME),MR-Egger,and weighted mode methods were used to validate the results.Sensitivity analyses of instrumental variables were performed to ensure the robustness of the analysis.Results Total of 10 SNPs strongly associated with VitB12 deficiency anemia were obtained as instrumental variables.I VW(OR=2.706,95％CI 1.357-5.396,P＜0.05),WME(OR=5.179,95％CI 2.678-10.015,P＜0.05),MR-Egger(OR=13.088,95％CI2.230-76.802,P＜0.05),and weighted mode(OR=5.699,95％CI 2.807～11.570,P＜0.05)results showed that the gene prediction of VitB12 deficiency anemia was significantly associated with the risk of T1D.Meanwhile the reverse MR study showed that T1D was not the cause of VitB12 deficiency anemia.Sensitivity analysis supported the reliability of the study findings.Conclusion This study sug-gests that VitB12 deficiency anemia is a risk factor for T1D,and there is a positive causal correlation between them.关键词
孟德尔随机化/维生素B12缺乏性贫血/1型糖尿病/单核苷酸多态性/因果推断Key words
Mendelian randomization/vitamin B12 deficiency anemia/type 1 diabetes/single nucleotide polymorphism/causal inference分类
医药卫生引用本文复制引用
赵晨玥,高景波,郭荣,曹桂芝,郭敏,岳昊,薛慧琴..孟德尔随机化探索维生素B12缺乏性贫血和1型糖尿病风险的因果关系[J].山西医科大学学报,2024,55(5):644-649,6.基金项目
山西省回国留学人员科研教研资助项目(2023-180) （2023-180）
山西省"四个一批"科技兴医创新计划项目"医学遗传学研究委级重点实验室建设项目(2021SY24) （2021SY24）
山西省儿童医院博士基金项目(201948) （201948）
山西省卫生健康委科研课题项目(2023016) （2023016）
