摘要
Abstract
Objective To analyze the relationship between blood routine indexes and 25-hydroxyvitamin D[25(OH)D]in children aged 0 to 3 years.Methods A total of 851 children aged 0 to 3 years who underwent physical examination in Beijing Wanliu Amcare Women's and Children's Hospital from January 2018 to December 2022 were selected for the cross-sectional study.The relationship between mean corpuscular volume(MCV)and 25(OH)D was analyzed by single factor correlation and regression analysis and multifactor linear regression model.Results Among the 851 children aged 0 to 3 years,the 25(OH)D levels ranged from 16.75 to 212.95 nmol/L,with an average of(84.54±31.11)nmol/L.There were 14 cases(1.65%)of vitamin D deficiency,108 cases(12.69%)of vitamin D inadequate,and no excessive vitamin D.The hemoglobin level was 83-151 g/L,66 cases were mild anemia(7.76%),3 cases were moderate anemia(0.35%),no severe anemia,the total anemia rate was 8.11%.Red blood cell count was(3.25-6.23)×1012/L,MCV was 52.8-98.8 fl.There were significant differences in MCV,maternal childbearing age,and physical examination month between 25(OH)D low level group and 25(OH)D high level group(P<0.05).Univariate correlation analysis:Pearson correlation coefficient(r)=0.105,P=0.001.Univariate regression analysis:Equation test F=9.401,P=0.002;Regression coefficient β=0.737(95%CI 0.265-1.209),t=3.066,P=0.002.Multifactor linear regression analysis showed that MCV was positively correlated with 25(OH)D.Higher levels of 25(OH)D were found in children who were examined between 1 May and 31 October each year,and levels of 25(OH)D decreased with the increase of monthly age(P<0.05).Conclusion MCV is positively correlated with the 25(OH)D level in children aged 0 to 3 years.MCV can be used as a sensitive index for the change of 25(OH)D.If the MCV level is found to be low in the blood routine examination,the nutritional status of vitamin D should be concerned.关键词
25羟维生素D/平均红细胞体积/贫血/0～3岁儿童Key words
25-hydroxyvitamin D/Mean corpuscular volume/Anemia/Children aged 0-3 years分类
医药卫生
