现代科学仪器2024，Vol.41Issue(3)：134-140,7.
基于HMGB1通路的盐酸戊乙奎醚对脑梗死的保护效应
The Protective Effect of Penehyclidine Hydrochloride on Cerebral Infarction via the HMGB1 Pathway
摘要
Abstract
Objective:To investigate the protective effect of penehyclidine hydrochloride on cerebral infarction based on the HMGB1 pathway.Methods:50 SD male rats were grouped to investigate the optimal dosage and effect of PHC in treating cerebral infarction,as well as to explore the role of the HMGB1 pathway.Results:PHC intervention can alleviate nerve cell damage,and its effect is correlated with the dosage.Compared with the sham operation group,multiple indicators in the model group and the PHC group are abnormal.However,compared with the model group,the indicators in the PHC group are improved,and the improvement is also related to the dosage.Inhibition of HMGB1 has the same effect as a high dose of PHC,which can improve brain tissue inflammation and oxidative stress,and reduce protein expression.PHC treatment is related to the inhibition of the HMGB1/TLR4/NF-κB pathway,and combined inhibition can enhance the effect..Conclusions:PHC has a protective effect on rats with cerebral infarction by inhibiting the HMGB1/TLR4/NF-κB pathway and downregulating the expression of inflammatory factors.关键词
盐酸戊乙奎醚/高迁移率组蛋白B1/Toll样受体4/核因子-κB/脑梗死Key words
Penehyclidine hydrochloride/High mobility group histone B1/Toll-like receptor 4/Nuclear factor-κB/Cerebral infarction分类
医药卫生引用本文复制引用
梁振生,张梦翔,杨晓丹,盛竹君,张楠,杨满琴,王保国,谢若男..基于HMGB1通路的盐酸戊乙奎醚对脑梗死的保护效应[J].现代科学仪器,2024,41(3):134-140,7.基金项目
安徽省自然科学基金项目(1908085QH371) （1908085QH371）
