妇儿健康导刊2024，Vol.3Issue(11)：66-69,4.
不同血清总胆汁酸水平对妊娠肝内胆汁淤积症患者肝功能和母婴结局的影响
Effect of different serum total bile acid levels on liver function and maternal and infant outcomes in patients with intrahepatic cholestasis of pregnancy
摘要
Abstract
Objective To analyze the effect of different serum total bile acid(TBA)levels on liver function and maternal and infant outcomes in patients with intrahepatic cholestasis of pregnancy(ICP).Methods A total of 60 patients with ICP from Zhuhai Center for Maternal and Child Health Care from January to December 2021 were selected as the study objects.According to the TBA levels,they were divided into control group(30 cases,TBA<40 μmol/L)and observation group(30 cases,TBA≥40 μmol/L).The serum levels of total bilirubin(TBiL),alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),gamma-glutamyl transferase(γ-GGT),and maternal and infant outcomes were compared between the two groups.Results The serum levels of TBiL,ALT,AST,ALP,andγ-GGT in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).The amniotic fluid contamination rate in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).The rates of premature birth and neonatal asphyxia in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).The Apgar scores in the observation group at 1 and 10 minutes after birth were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion ICP patients with high level of TBA have more serious liver function damage,and the incidence of adverse maternal and infant outcomes such as amniotic fluid contamination,premature delivery and neonatal asphyxia is higher.关键词
妊娠肝内胆汁淤积症/血清总胆汁酸/肝功能/母婴结局Key words
Intrahepatic cholestasis of pregnancy/Serum total bile acid/Liver function/Maternal and infant outcome分类
医药卫生引用本文复制引用
邱惠明,樊海健,丁芳川..不同血清总胆汁酸水平对妊娠肝内胆汁淤积症患者肝功能和母婴结局的影响[J].妇儿健康导刊,2024,3(11):66-69,4.基金项目
广东省珠海市科技计划项目(ZH22036201210169PWC). （ZH22036201210169PWC）
