有氧运动通过miR-34a/SIRT1通路调控自噬改善急性心肌梗死大鼠心肌损伤的作用机制OACSTPCD
Mechanism of aerobic exercise ameliorating myocardial injury in rats with acute myocardial infarction by regulating autophagy through miR-34a/SIRT1 pathway
目的 探讨有氧运动改善急性心肌梗死(AMI)大鼠心肌损伤的调控机制.方法 将 24 只雄性SD大鼠随机均分为假手术组、模型组和有氧运动组,每组8 只.通过结扎冠状动脉左前降支构建AMI模型,并对有氧运动组AMI大鼠进行持续4周的有氧运动干预;采用HE染色法和Masson染色法观察各组大鼠的心脏组织学形态和纤维化程度;通过ELISA检测大鼠血浆脑钠肽(BNP)含量;通过经胸超声心动图(TTE)评估缩短分数(FS)、射血分数(EF);RT-qPCR检…查看全部>>
Objective To explore the regulatory mechanism of aerobic exercise ameliorating myocardial injury in acute myocardial infarction(AMI)rats.Methods A total of 24 male SD rats were randomly divided into sham-operated group,model group and aerobic exercise group,eight in each group.AMI model was constructed by ligating the left anterior descending branch of the coronary artery.Rats in the aerobic exercise group was subjected to 4 consecutive weeks of aerobic exer…查看全部>>
吴爱萍;朱悦红;夏婉;章睿
310013 杭州,浙江医院康复医学科310013 杭州,浙江医院康复医学科310013 杭州,浙江医院康复医学科310013 杭州,浙江医院康复医学科
急性心肌梗死有氧运动自噬微小RNA-34a
Acute myocardial infarctionAerobic exerciseAutophagyMiR-34a
《心脑血管病防治》 2024 (5)
13-18,51,7
浙江省医药卫生科技计划项目(2019KY002)浙江省中医药科技计划项目(2020ZB004)
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