基于Wnt/β-catenin通路介导的上皮间质转化探讨电针治疗宫腔粘连大鼠子宫内膜纤维化的作用机制OA北大核心CSTPCDMEDLINE
Mechanism of electroacupuncture in treating uterine endometrial fibrosis in intrauterine adhesions rats based on Wnt/β-catenin pathway-mediated epithelial-mesenchymal transition
目的:观察电针对宫腔粘连(IUA)大鼠子宫内膜Wnt/β-连环蛋白(β-catenin)信号通路与上皮间质转化(EMT)相关蛋白的影响,探讨其修复IUA子宫内膜的可能机制.方法:雌性SD大鼠随机分为空白组、模型组、电针组、ICG-001组,每组10只.采用机械搔刮联合脂多糖感染双重损伤法制备IUA模型.电针组针刺"关元",电针双侧"足三里""三阴交",20 min/次,1次/d;ICG-001组腹腔注射β-catenin抑制剂ICG-001(5 …查看全部>>
Objective To observe the effect of electroacupuncture(EA)on the Wnt/β-catenin signaling pathway and epithelial-mesenchymal transition(EMT)-related proteins in rats with intrauterine adhesions(IUA),so as to explore the possible mechanisms of EA in repairing endometrial damage in IUA.Methods Female SD rats were randomly divided into blank,model,EA,and ICG-001 groups,with 10 rats in each group.The IUA model was established by using mechanical scraping combined …查看全部>>
李军威;夏良君;崔础婷;程洁;夏有兵
南京中医药大学针灸推拿学院·养生康复学院,南京 210046南京中医药大学针灸推拿学院·养生康复学院,南京 210046南京中医药大学针灸推拿学院·养生康复学院,南京 210046南京中医药大学针灸推拿学院·养生康复学院,南京 210046南京中医药大学针灸推拿学院·养生康复学院,南京 210046||南京医科大学,南京 211166
宫腔粘连电针子宫内膜纤维化Wnt/β-连环蛋白通路上皮间质转化
Intrauterine adhesionsElectroacupunctureEndometrial fibrosisWnt/β-catenin pathwayEpithelial-mesenchymal transition
《针刺研究》 2024 (6)
566-576,11
国家自然科学基金项目(No.82205251、82274638)江苏省高校自然科学研究重大项目(No.23KJA360006)江苏省研究生科研创新计划(No.KYCX23_2151)
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