针刺研究2024，Vol.49Issue(6)：650-660,11.DOI:10.13702/j.1000-0607.20230020
基于神经影像学的常见神经系统疾病头针刺激靶点研究(上)
Scalp acupuncture targets for neurological disorders:evidence from neuroimaging studies(part 1)
摘要
Abstract
Objective Scalp acupuncture is a unique acupuncture method developed based on brain functional and pathophysiological knowledge.In past decades,there has been significant development in the understanding of the brain pathology of many neurological disorders through cutting-edge brain imaging techniques.Yet,these findings have not been incorporated into scalp acupuncture.In the present paper,we aimed to initiate an attempt to develop/identify scalp acupuncture targets based on neuroimaging findings.Methods Based on the meta-analysis of neuroimaging studies in the Neurosynth database platform(http://neurosynth.org/),the brain clusters related to neurological disorders were automatically identified according to the search terms"Parkinson's disease"(PD),"chronic pain"(CP),"aphasia"(APH),"dyslexia"(DYS),"mild cognitive impairment","Alzheimer's disease"and"dementia".Subsequently,the discovered brain region clusters projected onto the brain surface and scalp surface were listed,and the peak points of the clusters projected to the scalp surface were proposed as the potential stimulation targets for the corresponding diseases.Further,by combining the traditional scalp acupoints(including the scalp acupuncture lines)with 10-20 EEG system sites,we made localization suggestions for scalp stimulation targets and made acupuncture operation suggestions by combining with the shape of the brain region clusters.The literature search was conducted on July 30,2022.Results The localization and manipulation suggestions of neuroimage-based scalp acupuncture targets were introduced in two parts.This part(part 1)includes PD,CP,APH,and DYS.Here are 3 target examples of each of these 4 diseases simply introduced due to word limitation.1)PD.Based on the 175 articles retrieved from Neurosynth,we identified 7 potential scalp acupuncture targets for PD,the locations of the acupuncture stimulation and the recommended acupuncture needle operation(RANO)as well as the corresponding brain regions(CBRs)respectively are as below.PD1:about 0.5 cun(1 cun≈33.3 mm)superior-posterior to the left Xuanlu(GB5);puncturing subcutaneously and forward-upward;the left premotor area,subfrontal cortex of the island,inferior frontal gyrus and middle frontal gyrus.PD2:about 1 cun lateral-inferior to the left Chengling(GB18);puncturing subcutaneously and backward-upward;the inferior parietal lobule and postcentral gyrus.PD3:about 0.5 cun lateral-anterior to the left GB18;puncturing subcutaneously and inward-backward;left anterior central gyrus and posterior central gyrus.2)CP.Based on the retrieved 92 articles,we identified 8 potential scalp acupuncture targets,the location of the acupuncture stimulation and the RANO,and CBRs respectively are as below.CP1:about 1 cun anterior-inferior to the left Xuanli(GB8);puncturing subcutaneously and backward-inwards;the left inferior frontal gyrus orbitalis and pars triangularis.CP2:about 0.5 cun posterior-superior to the left GB5;puncturing subcutaneously and forward-upward;the left anterior central gyrus and premotor area.CP3:about 0.5 cun posterior-superior to the left GB8;puncturing subcutaneously and forward;left inferior central area/central sulci operculum(second somatosensory area).3)APH.Based on the retrieved 82 papers,we identified 7 potential scalp acupuncture targets for APH,their locations,RANO,and CBRs respectively are as below.APH1:close to the left GB5;puncturing subcutaneously and forward-downward;left subfrontal gyrus operculi/triangularis.APH2:about 0.5 cun posterior to the left Hanyan(GB4);puncturing subcutaneously and backward-upward;the left anterior central gyrus and posterior central gyrus.APH3:about 0.5 cun anterior-inferior to the left Qubin(GB7);puncturing subcutaneously and backward-downward;left medial/superior temporal gyrus.4)DYS.Based on the retrieved 76 researches,we identified 8 potential scalp acupuncture targets for DYS,their locations,RANO and CBRs respectively are as below.DYS1:about 1 cun anterior-inferior to the left GB5;puncturing subcutaneously and forward-upward;the pars triangularis of the left inferior frontal gyrus.DYS2:about 0.5 cun posterior-superior to the left GB5;puncturing subcutaneously and forward-downward;the left subfrontal gyrus operculum,pars triangularis and anterior central gyrus.DYS3:the midpoint between the left GB5 and GB18;puncturing subcutaneously and forward;the left anterior central gyrus and posterior central gyrus.Conclusion We identified scalp acupuncture targets for several common neurological disorders based on neuroimaging evidence for clinical application and research.The proposed targets may also be used for treating these disorders using brain stimulation methods.关键词
头针/头针刺激靶点/神经成像/神经系统疾病/脑刺激Key words
Scalp acupuncture/Scalp acupuncture stimulation targets/Neuroimaging/Neurological disorders/Brain stimulation引用本文复制引用
张斌龙,刘娇,崔方圆,曹瑾,余思奕,孔乔,孔健..基于神经影像学的常见神经系统疾病头针刺激靶点研究(上)[J].针刺研究,2024,49(6):650-660,11.基金项目
国家自然科学基金项目(No.82205299、82004303) （No.82205299、82004303）
中国科协青年人才托举工程项目(No.2022QNRC001) （No.2022QNRC001）
中国中医科学院优秀青年科技人才培养专项(No.ZZ14-YQ-017) （No.ZZ14-YQ-017）
中国中医科学院科技创新工程项目(No.CI2021A03316) （No.CI2021A03316）
