摘要
Abstract
Objective To explore the effect of tacrolimus on the severity of illness,activity of daily living,and clinical outcomes of patients with chronic inflammatory demyelinating polyradiculoneuropathy(CIDP).Methods A random number table method was used to divide 40 patients with CIDP admitted to Ordos Central Hospital in Inner Mongolia from January 2018 to August 2021 into the control group and the study group,with 20 cases in each group.The control group received first-line induction therapy combined with prednisone treatment,while the study group received first-line induction therapy combined with tacrolimus treatment.The clinical symptom relief time,limb motor function,neurological function,activity of daily living,severity of illness,adverse reactions,liver and kidney function indicators,and clinical outcomes of the two groups were compared.Results The relief time of sensory disorders,limb weakness,limb pain,and abnormal tendon reflex between the two group was compared,without statistically significant difference(P>0.05).After the treatment,the scores of the Medical Research Council(MRC)muscle strength assessment grading scale and Barthel index(BI)assessment scale in both groups were higher than those before the treatment,while the American Spinal Injury Association(ASIA)neurological function score was lower than that before the treatment,with statistically significant difference(P<0.05).The MRC muscle strength assessment scale grading,BI assessment scale,and ASIA neurological function score after the treatment were compared between the two groups,without statistically significant differences(P>0.05).The degree of improvement of illness was compared between the two groups,without statistically significant difference(P>0.05).The incidence of adverse reactions,liver and kidney function indicators,recurrence rate,and mortality rate were compared between the two groups,without statistically significant differences(P>0.05).Conclusion The clinical efficacy of tacrolimus is comparable to that of prednisone,and it can alleviate clinical symptoms,and improve limb motor function,neurological function,and activity of daily living in a short period,with high safety.关键词
慢性炎性脱髓鞘性多发性神经根神经病/他克莫司/神经功能/日常生活能力/临床结局Key words
Chronic inflammatory demyelinating polyradiculoneuropathy/Tacrolimus/Neurological function/Activity of daily living/Clinical outcomes分类
医药卫生
