中国医药科学2024，Vol.14Issue(10)：111-114,131,5.DOI:10.20116/j.issn2095-0616.2024.10.27
肝细胞癌患者TACE治疗后新发心血管疾病的危险因素分析
Analysis of risk factors of new cardiovascular disease in patients with hepatocellular carcinoma after TACE treatment
摘要
Abstract
Objective To explore the risk factors of cardiovascular diseases in patients with hepatocellular carcinoma within 6 months after transcatheter arterial chemoembolization(TACE).Methods The clinical data of 155 hepatocellular carcinoma patients treated with TACE in the First Affiliated Hospital of Xinxiang Medical University from May 1,2020 to June 30,2023 were analyzed retrospectively.After the exclusion of incomplete data and lost patients,a total of 105 patients were included for analysis.Patients were divided into two groups according to whether cardiovascular disease occurred after TACE treatment,and independent risk factors were determined by multivariate analysis.Results Among the 105 hepatocellular carcinoma patients,29(27.6%)developed cardiovascular disease within six months.Follow-up revealed that 29 patients developed various degrees of arrhythmias.In addition,8 of these patients with arrhythmias developed angina pectoris between weeks 2 and 8 after TACE,5 patients developed heart failure between weeks 3 and 12,3 patients developed myocarditis between weeks 13 and 24,and 2 patients developed acute myocardial infarction at week 2,accounting for 62.1%of total cardiovascular disease cases.Independent risk factors included liver function grade B,diabetes,hyperlipidemia,TACE treatment for more than 3 times and irregular exercise(OR>1 and P<0.05).The area under the curve value of the receiver operating characteristic predicted by multi-factors was 0.782(95%CI:0.683-0.882),which showed good prediction efficiency.Conclusion The risk of cardiovascular disease in patients with hepatocellular carcinoma after TACE should be paid attention.For patients with related risk factors,we should actively control the basic diseases and increase physical activity.关键词
肝细胞癌/经导管动脉化疗栓塞/心血管疾病/危险因素Key words
Hepatocellular carcinoma/Transcatheter arterial chemoembolization/Cardiovascular diseases/Risk factor分类
医药卫生引用本文复制引用
靳远,齐劲松,刘保清,解娜..肝细胞癌患者TACE治疗后新发心血管疾病的危险因素分析[J].中国医药科学,2024,14(10):111-114,131,5.基金项目
新乡医学院第三附属医院开放课题(KFKTYB202123). （KFKTYB202123）
