摘要
Abstract
Objective To explore the efficacy of Escitalopram,Agomelatine combined with irbesartan hydrochlorothiazide in the treatment of depression complicated with hypertension.Methods A total of 100 patients with depression combined with hypertension admitted to Beijing Changping District Hospital of Integrated Traditional Chinese and Western Medicine from February 2020 to March 2022 were selected as the study objects,and were divided into experimental group(n=50)and control group(n=50)by random number table method.Both groups were treated with irbesartan hydrochlorothiazide to reduce blood pressure,while the control group was treated with escitalopram for antidepressant treatment,and the experimental group was treated with escitalopram combined with agomelatine for antidepressant treatment.Hamilton Depression Scale(HAMD)was used to evaluate patients'depression before and after treatment,and negative cognitive Processing Bias Questionnaire(NCPBQ)was used to evaluate patients'negative cognition.The levels of 5-hydroxytryptamine(5-HT),brain-derived neurotrophic factor(BDNF)before and after treatment,TESS score and incidence of adverse reactions were compared between the two groups.Results After treatment,HAMD and NCPBQ scores of the two groups were decreased,and the test group was lower than the control group,the difference was statistically significant(P＜0.05).After treatment,the levels of 5-HT and BDNF of the two groups were increased,and the test group were higher than those in control group,and the difference was statistically significant(P＜0.05).After 4 and 8 weeks of treatment,TESS scores of experimental groups were lower than those of control group,but the difference was not statistically significant(P＞0.05).There was no significant difference in the incidence of adverse reactions between experimental group and control group(P＞0.05).Conclusion Escitalopram,agomelatine combined with irbesartan hydrochlorothiazide in the treatment of depression complicated with hypertension can further reduce the blood pressure level,reduce the degree of depression and negative cognition,and regulate the expression levels of serum 5-HT and BDNF,with high safety.关键词
艾司西酞普兰/阿戈美拉汀/厄贝沙坦氢氯噻嗪/抑郁症/高血压/疗效/安全性Key words
Citalopram/Agomelatine/Irbesartan hydrochlorothiazide/Depression/Hypertension/Curative effect/Security分类
医药卫生
