温针灸联合辛伐他汀治疗痰瘀结滞证高脂血症患者的临床疗效OA
Clinical Effect of Warm Acupuncture combined with Simvastatin in the Treatment of Hyperlipidemia Patients with Phlegm and Blood Stasis Syndrome
目的 探讨温针灸联合辛伐他汀治疗痰瘀结滞证高脂血症患者的临床疗效.方法 选取2023 年1-10 月长沙市中医医院针灸康复科、心血管内科门诊收治的 120 例痰瘀结滞证高脂血症患者为研究对象,按随机分配原则分为观察 1 组、观察2 组、对照组,每组40 例.3 组均予以治疗性生活方式改变(TLC)后,观察1 组进行单纯温针灸治疗,观察2 组进行温针灸+辛伐他汀治疗,对照组采用辛伐他汀治疗.比较 3 组患者治疗前后血脂水平变化情况、载脂蛋白a1(ApoA1)水平、生命质量评分及中医证候积分.结果 治疗后,观察 1 组、观察 2 组三酰甘油(TG)、胆固醇(TC)及低密度脂蛋白胆固醇(LDL-C)水平低于对照组,高密度脂蛋白胆固醇(HDL-C)水平高于对照组,且观察2 组各指标下降/提升幅度更大,差异有统计学意义(P＜0.05);治疗后,观察1 组、观察2 组ApoA1 水平高于对照组,且观察2 组提升幅度更大,差异有统计学意义(P＜0.05);治疗后,观察 1 组、观察 2 组生理功能、生理职能、躯体功能、活力、社会功能、情感职能、心理健康、总体健康状态评分高于对照组,且观察2 组提升幅度更大,差异有统计学意义(P＜0.05);治疗后,观察 1组、观察 2 组中医证候积分低于对照组,且观察 2 组下降幅度更大,差异有统计学意义(P＜0.05).结论 痰瘀结滞证高脂血症患者采用温针灸联合辛伐他汀治疗,可有效调节血脂水平,改善症状,提高生命质量.
Objective To explore the clinical efficacy of warm acupuncture combined with simvastatin in the treatment of hyperlipidemia patients with phlegm and blood stasis syndrome.Methods A total of 120 patients with hyperlipidemia of phlegm-stasis syndrome admitted to the Department of Acupuncture and Rehabilitation and cardiovascular Medicine Outpatient Department of Changsha Hospital of Traditional Chinese Medicine from January 2023 to October 2023 were selected as the study subjects,and were divided into observation group 1,observation group 2 and control group according to the principle of random allocation,with 40 cases in each group.After treatment with therapeutic lifestyle change(TLC),observation group 1 received warm acupuncture alone,observation group 2 received warm acupuncture plus simvastatin,control group received simvastatin treatment.The changes of blood lipid level,apolipoprotein a1(ApoA1)level,quality of life score and TCM syndrome score were compared before and after treatment in 3 groups.Results After treatment,the levels of triglyceride(TG),cholesterol(TC)and low density lipoprotein cholesterol(LDL-C)in observation group 1 and observation group 2 were lower than those in control group,while the levels of high density lipoprotein cholesterol(HDL-C)were higher than those in control group,and the indexes in observation group 2 were decreased/increased more,the difference was statistically significant(P＜0.05).After treatment,ApoA1 level in observation group 1 and observation group 2 was higher than that in control group,and the increase of APOA1 level in observation group 2 was greater,the difference was statistically significant(P＜0.05).After treatment,the scores of physiological function,physiological function,physical function,vitality,social function,emotional function,mental health and overall health status of observation group 1 and observation group 2 were higher than those of control group,and the improvement of observation group 2 was greater,the difference was statistically significant(P＜0.05).After treatment,the TCM syndrome score of observation group 1 and observation group 2 was lower than that of control group,and the decrease of observation group 2 was greater,the difference was statistically significant(P＜0.05).Conclusion In patients with hyperlipidemia of phlegm-stasis syndrome,warm acupuncture combined with simvastatin can effectively regulate blood lipid levels,improve symptoms and improve life quality.
徐润蕾;邢敏;卢享君;王创新;朱瑞欣;杜革术
湖南中医药大学,长沙 410208||长沙市中医医院针灸康复科,长沙 410100湖南中医药大学,长沙 410208长沙市中医医院针灸康复科,长沙 410100长沙市中医医院心血管内科,长沙 410100
临床医学
温针灸辛伐他汀高脂血症载脂蛋白
Warm acupunctureSimvastatinHyperlipidemiaApoprotein
《中国药物经济学》 2024 (005)
46-50 / 5
湖南省自然科学基金项目(2023JJ60075);长沙市自然科学基金项目(kq2208492);湖南省中医药科研计划项目(B2023113);长沙市中医医院(长沙市第八医院)2023年院级一般课题(202310);国家中医药管理局第七批全国老中医药专家学术经验传承工作指导老师人才培养项目[国中医药人教函(2022)76号];湖南省"十四五"第二批中医药学科带头人人才培养项目[湘中医药(2024)3号]
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