傅健英 1蔡晓东 1马小花 1王升勇 1刘春瑶 1陈凡1
作者信息
- 1. 海南卫生健康职业学院药学系,海口 571000
- 折叠
摘要
Abstract
Objective To evaluate the effectiveness and safety of callicarpae nudiflorae combined with antibiotics in treatment of bacterial infectious disease,in order to provide basis for evidence-based in the rationality of the combination.Methods PubMed,EMBase,Cochrane library,CNKI,VIP and Wanfang database were researched from inception to May 2022.Meta-analysis was performed by using RevMan 5.3 software.Results A total of 23 clinical controlled trials were included.Meta-analysis showed that total response rate[RR=1.20,95%CI(1.14～1.26),P＜0.000 01],antipyretic time[MD=-2.13,95%CI(-3.45～-0.80),P=0.002],WBC[MD=0.77,95%CI(0.01～1.52),P=0.05],PCT[MD=1.14,95%CI(0.50～1.78),P=0.000 5],CRP[MD=1.44,95%CI(0.91～1.97),P＜0.000 01],IL-6[MD=0.97,95%CI(0.04～1.90),P=0.04]of experiment group were better than those of control group.Fourteen trials were included outcome indicators of adverse reactions.From the results of meta-analysis,experiment group was same to the control group in the incidence of adverse drug reaction without statistical difference[RR=0.91,95%CI(0.58～1.43),P=0.69].Conclusion The combined antibacterial drugs can significantly improve the total effective rate of the treatment of bacterial infectious diseases,shorten the fever time,and reduce the levels of WBC,PCT,CRP and IL-6,and there is no significant difference in the incidence of adverse reactions between the two groups.关键词
裸花紫珠/抗菌药物/细菌感染性疾病/Meta分析Key words
Callicarpae nudiflorae/Antibiotics/Bacterial infectious disease/Meta-analysis分类
医药卫生
