中国药物经济学2024，Vol.19Issue(5)：82-89,8.DOI:10.12010/j.issn.1673-5846.2024.05.014
补肾壮骨汤治疗原发性骨质疏松症的Meta分析
Meta-analysis of Bushen Zhuanggu Decoction in the Treatment of Primary Osteoporosis
摘要
Abstract
Objective To evaluate the efficacy and safety of Busen Zhuanggu Decoction in the treatment of primary osteoporosis(POP)systematically.Methods PubMed,EMbase,The Cochrane Library,Web of Science,CBM,Wan Fang data,VIP and CNKI databases were searched.Randomized controlled trials(RCTS)on the efficacy and safety of Bushen Zhuanggu Decoction in the treatment of primary osteoporosis were have retrievaled,and the retrieval period was from the self-established database date to July 1,2021.Two researchers independently conducted literature retrieval,screening,data extraction,and evaluation of literature quality and the risk of bias in the study,and then used RevMan 5.3 software to conduct meta-analysis.Results Eighteen RCTS were included,including 2 226 patients.The results of meta-analysis showed that:Compared with the control group,busen Zhuang Gu Decoction could significantly improve the effective rate[OR=5.02,95%CI(3.74～6.74),P＜0.000 01],and increase the lumbar spine bone density[MD=0.07,95%CI(0.01～0.13),P=0.02],decreased visual analog pain score(VAS)[MD=-0.99,95%CI(-1.27～-0.71),P＜0.000 01],improved the score of TCM syndromes of back pain[MD=-0.59,95%CI(-0.65～-0.52),P＜0.000 01],and the difference was statistically significant.There was no significant differences in the incidence of adverse reactions compared with the control group[OR=0.74,95%CI(0.30～1.80),P=0.05].Conclusion Compared with western medicine,Busen Zhuanggu Decoction can effectively relieve pain symptoms,strengthen bone and improve motor function in the treatment of primary osteoporosis,which is safe and effective.关键词
补肾壮骨汤/原发性骨质疏松症/随机对照试验/Meta分析Key words
Busen Zhuanggu Decoction/Primary osteoporosis/Randomized controlled trial/Meta analysis分类
医药卫生引用本文复制引用
刘叶荣,杜松,陈苗苗,章雅儒,吴锦玉,杨泽宇,成玲,肖霞萍..补肾壮骨汤治疗原发性骨质疏松症的Meta分析[J].中国药物经济学,2024,19(5):82-89,8.基金项目
甘肃省自然科学基金(22JR5RA631) （22JR5RA631）
