中年女性-全身骨痛-低磷血症OA北大核心CSTPCD

Tumor-induced osteomalacia(TIO)is a rare acquired metabolic bone disease.TIO tumors are often occult,small and widely distributed and are even rare in the brain.This article reports a 44-year-old female patient who developed pain and weakness in lower limbs 3 years ago,and gradually developed systemic bone pain,mobility disorders,and multiple fractures.Laboratory examination indicated that hypophosphatemia and high alkaline phosphatase(ALP),and fibroblast growth factor-23(FGF-23)levels were significantly increased,and TIO was considered.68 Ga-DOTATATE PET/CT whole-body imaging revealed a space beside the left frontal lobe sickle of the brain.After further confirmation by MR of the head,total resection of the tumor was performed.After surgery,blood phosphorus gradually returned to normal level,FGF-23 level decreased,and systemic bone pain disappeared,and pathological examination confirmed that the tumor was phosphaturic mesenchymal tumor(PMT).