中华骨质疏松和骨矿盐疾病杂志2024，Vol.17Issue(2)：137-144,8.DOI:10.3969/j.issn.1674-2591.2024.02.006
中年女性-全身骨痛-低磷血症
Middle-aged female-generalized bone pain-hypophosphatemia
魏祺 1单慈 2章振林2
作者信息
- 1. 200233 上海,上海交通大学附属第六人民医院骨质疏松与骨病科,上海市骨疾病临床研究中心||215000 江苏苏州,苏州大学附属第二医院骨质疏松症临床中心
- 2. 200233 上海,上海交通大学附属第六人民医院骨质疏松与骨病科,上海市骨疾病临床研究中心
- 折叠
摘要
Abstract
Tumor-induced osteomalacia(TIO)is a rare acquired metabolic bone disease.TIO tumors are often occult,small and widely distributed and are even rare in the brain.This article reports a 44-year-old female patient who developed pain and weakness in lower limbs 3 years ago,and gradually developed systemic bone pain,mobility disorders,and multiple fractures.Laboratory examination indicated that hypophosphatemia and high alkaline phosphatase(ALP),and fibroblast growth factor-23(FGF-23)levels were significantly increased,and TIO was considered.68 Ga-DOTATATE PET/CT whole-body imaging revealed a space beside the left frontal lobe sickle of the brain.After further confirmation by MR of the head,total resection of the tumor was performed.After surgery,blood phosphorus gradually returned to normal level,FGF-23 level decreased,and systemic bone pain disappeared,and pathological examination confirmed that the tumor was phosphaturic mesenchymal tumor(PMT).关键词
肿瘤骨软化症/低磷血症/颅内/成纤维细胞生长因子23Key words
tumor-induced osteomalacia/hypophosphatemia/intracranial/fibroblast growth factor-23分类
医药卫生引用本文复制引用
魏祺,单慈,章振林..中年女性-全身骨痛-低磷血症[J].中华骨质疏松和骨矿盐疾病杂志,2024,17(2):137-144,8.
