北京中医药大学学报2024，Vol.47Issue(6)：741-746,6.DOI:10.3969/j.issn.1006-2157.2024.06.001
基于血浊理论探讨氧化应激与心肌纤维化的关系及中医辨治
Exploration on the relationship between oxidative stress and myocardial fibrosis based on the theory of turbid blood and the traditional Chinese medicine differentiation and treatment
摘要
Abstract
Myocardial fibrosis is characterized by pathological remodeling of extracellular matrix,which is a common pathological change during the development of various cardiovascular diseases.Qi transformation dysfunction in the zang-fu organs,subtle substance accumulation,and endogenous turbid evil production lead to the occurrence of diseases.The theory of turbid blood is widely used to elucidate the pathological changes of diseases and guide the prevention and treatment.Turbid blood,as a special pathogenic factor and pathological product,plays a crucial role in the oxidative stress process of myocardial fibrosis.Qi deficiency of the heart and spleen,stagnation of turbid blood,impaired blood circulation in the heart,and the inability to maintain the oxidative-reductive system balance of myocardial cells are the root causes of disease onset.Accumulation of turbid blood,intermingled phlegm and blood stasis,blockage of heart vessels,and accumulation of metabolic waste products contribute to disease progression.Prolonged turbidity accumulation leads to cardiac enlargement,scattered mental state,and pathological remodeling of the extracellular matrix,indicating a severe disease stage.Early treatment focuses on strengthening the vital qi and spleen,reducing turbidity and recovering clarity.In the middle stage,the key is to resolve phlegm,eliminate stasis,and promote clarity while removing turbidity.In the late stage,detoxification,turbidity elimination,and restoring clarity are emphasized.By adhering to the characteristics of the pathological mechanism and using traditional Chinese medicine intervention,it is possible to suppress oxidative stress,prevent pathological remodeling of the extracellular matrix,and improve myocardial fibrosis.关键词
血浊理论/心肌纤维化/氧化应激/辨证论治Key words
theory of turbid blood/myocardial fibrosis/oxidative stress/syndrome differentiation and treatment分类
医药卫生引用本文复制引用
贾思涵,连妍洁,尚菊菊,刘红旭,李思耐..基于血浊理论探讨氧化应激与心肌纤维化的关系及中医辨治[J].北京中医药大学学报,2024,47(6):741-746,6.基金项目
国家自然科学基金面上项目(No.82174106) （No.82174106）
国家中医药管理局中医药循证能力建设项目-专科专病循证能力提升(No.2019XZZX-XXG001) （No.2019XZZX-XXG001）
首都医科大学附属北京中医医院科技发展基金资助项目(No.LYYB202303) National Natural Science Foundation of China(No.82174106) （No.LYYB202303）
