北京中医药大学学报2024，Vol.47Issue(6)：753-759,7.DOI:10.3969/j.issn.1006-2157.2024.06.003
益养丸对分化型甲状腺癌术后气阴两虚证患者心血管不良反应的防治作用
Preventive and therapeutic effects of Yiyang Pill in treating cardiovascular adverse reactions post-surgery in patients with differentiated thyroid cancer and qi and yin deficiency syndrome
摘要
Abstract
Objective To evaluate the effectiveness and safety of Yiyang Pill in preventing and treating cardiovascular adverse reactions in patients with traditional Chinese medicine(TCM)syndrome with qi and yin deficiency and thyroid stimulating hormone(TSH)inhibition after differentiated thyroid cancer(DTC)resection.Methods A randomized,double-blind,placebo-controlled clinical trial was conducted,and 120 patients with TSH inhibition after DTC surgery were enrolled and randomized into two groups in a 1∶1 ratio using SAS 9.4 software generated random tables.The control group received a placebo and TSH suppression therapy,whereas the treatment group received the Yiyang Pill and TSH suppression therapy.The treatment period was 3 months.The incidence of cardiovascular adverse reactions,blood pressure,blood lipids,thyroid function,the dosage of levothyroxine,the efficacy of TCM syndrome,and safety indicators were compared between the two groups.Multivariate Logistic regression was used to analyze the influencing factors of cardiovascular adverse reactions.Results The incidence of cardiovascular adverse reactions in the treatment group was lower than that in the control group(P<0.05),and the efficacy of TCM syndrome treatment was significantly higher than in the control group(P<0.05).The free tetraiodothyronine level in the treatment group was higher than that before treatment(P<0.05),and the systolic and diastolic blood pressure in the control group increased compared to those before treatment(P<0.05).No severe adverse events were observed in either group.Compared with the control group,the cardiovascular incidence in the treatment group was lower,and the cardiovascular incidence in the<100 μg/d group was lower than that in the group with≥100 μg/d before treatment.Conclusion The Yiyang Pill can reduce the incidence of cardiovascular adverse reactions in patients after DTC surgery,effectively improve TCM syndromes,and be safe to use.Yiyang Pill treatment is a protective factor for cardiovascular adverse reactions,and the dosage of levothyroxine≥100 μg/d was a risk factor.关键词
益养丸/气阴两虚证/分化型甲状腺癌术后/促甲状腺素抑制治疗/心血管不良反应Key words
Yiyang Pill/qi and yin deficiency pattern/postoperative differentiated thyroid cancer/thyroid stimulating hormone inhibition/cardiovascular adverse reactions分类
医药卫生引用本文复制引用
陆钰原,乔佳君,刘昕怡,楚爱景,刘守尧,夏仲元..益养丸对分化型甲状腺癌术后气阴两虚证患者心血管不良反应的防治作用[J].北京中医药大学学报,2024,47(6):753-759,7.基金项目
国家高水平医院临床业务费专项临床研究项目(No.2022-NHLHCRF-LX-02-0115) （No.2022-NHLHCRF-LX-02-0115）
首都特色临床应用研究资助项目(No.Z181100001718141) National High-Level Hospital Clinical Research Funding(No.2022-NHLHCRF-LX-02-0115) （No.Z181100001718141）
