成都大学学报（自然科学版）2024，Vol.43Issue(2)：120-129,10.DOI:10.3969/j.issn.1004-5422.2024.02.002
中药调节细胞因子水平治疗失眠研究进展
Research Progress in Treatment of Insomnia by Regulating Cytokine Levels in Traditional Chinese Medicine
摘要
Abstract
This study aims to review the progress in using single Chinese herbs,traditional Chinese medi-cine(TCM)monomers,TCM formulas,and TCM preparations to regulate cytokines for the treatment of in-somnia,and provide ideas for the prevention and treatment of insomnia.Relevant literature on cytokine regulation of insomnia was retrieved from domestic and foreign databases established from the database es-tablishment to 2023,and 61 standard articles were included in the review through inclusion and exclusion criteria.The mechanisms by which different types of TCM regulate cytokines to treat insomnia mainly fo-cus on regulating ILs and TNF,thereby alleviating insomnia.Different types of TCM can respectively regu-late TLR4/NF-κB signaling pathway,NLRP3 inflammasome pathway,SIRT1/NF-κB signaling pathway,brain CREB/BDNF/TrkB signaling pathway,and Th1/Th2 differentiation,etc.,to modulate the release of inflammatory factors ILs and TNF,and alleviate insomnia and ameliorate the insomnia-induced complica-tions such as anxiety and cognitive disorders.关键词
失眠/中药/细胞因子/研究进展Key words
insomnia/traditional Chinese medicine/cytokines/research progress分类
医药卫生引用本文复制引用
严雪,周文月,周森林,童宇,时政..中药调节细胞因子水平治疗失眠研究进展[J].成都大学学报（自然科学版）,2024,43(2):120-129,10.基金项目
四川省科技厅农业科技成果转化资金项目(2022NZZJ0015) （2022NZZJ0015）
四川省2021-2023年高等教育人才培养质量和教学改革项目(JG2021-1103) （JG2021-1103）
龙泉驿英才计划C类创新人才计划项目(90) （90）
成都大学附属医院院级课题(Y2021006、Y202232、Y202234) （Y2021006、Y202232、Y202234）
成都大学临床医学院/附属医院创新团队项目(CDFYCX202208) （CDFYCX202208）
