电化学（中英文）2024，Vol.30Issue(5)：1-10,10.DOI:10.61558/2993-074X.3442
电化学脱卤氘化研究进展
Recent Advance in Electrochemical Dehalogenative Deuteration
李鹏飞 1寇广生 1亓丽萍 1仇友爱1
作者信息
- 1. 南开大学化学院元素有机化学国家重点实验室,天津 300071
- 折叠
摘要
Abstract
In recent years,the incorporation of deuterium atoms into organic compounds has emerged as a vital focus in the development of pharmaceutical molecules.This trend is driven by the increasing recognition of the significance of compounds containing deuterium atoms across various domains,including materials and biopharmaceuticals,where they have found widespread applications in mechanistic studies within the realms of chemistry and biology.Meanwhile,organic electrochemistry,as a relatively environmentally friendly catalytic mode with broad adaptability to redox reactions,has emerged as a crucial alternative to traditional halogen-deuterium exchange in the context of the reduction deuteration of halides.This approach circumvents the uses of transition metal catalysts and toxic deuterated reagents which are commonly employed in traditional methods.Notably,electrocatalytic dehalogenation with deuterium incorporation typically relies on heavy water as the deuterium source,ensuring high yields and significant deuterium incorporation.In recent years,electrochemically dehalogenative deuteration of halides has made substantial progress,providing critical support for the synthesis and development of deuterated compounds.This article offers a comprehensive overview of the latest advancements in electrochemical reductive deuteration of both aromatic and alkyl halides,categorizing the progress according to the type of halide and delving into the un-derlying reaction mechanisms.关键词
电化学/氘化/卤化物/氘水/脱卤反应Key words
Electrochemistry/Deuteration/Halide/Deuterium oxide/Dehalogenation引用本文复制引用
李鹏飞,寇广生,亓丽萍,仇友爱..电化学脱卤氘化研究进展[J].电化学（中英文）,2024,30(5):1-10,10.
