术前外周血血小板/淋巴细胞比值在肝细胞癌术后微血管侵犯预测中的价值OACSTPCD

Objective To explore the related risk factors of postoperative microvascular invasion(MVI)in hepatocellular carcinoma(HCC)and the value of preoperative peripheral blood platelet-to-lymphocyte ratio(PLR)in predicting MVI after HCC surgery.Methods A total of 166 HCC patients,who received radical resection in the First Affiliated Hospital of Xi'an Jiaotong University from Jan.2017 to Dec.2018,were retrospectively analyzed.Fourteen factors that might affect the occurrence of MVI were included in this study,including general observation index(gender,age,history of hepatitis,with/without diabetes mellitus),laboratory related indicators(D-dimer,fibrinogen,plasma fibrinogen degradation products,platelet count,alpha fetoprotein,neutrophil to lymphocyte ratio,and PLR),and tumor related factors(with/without portal vein tumor thrombus,tumor differentiation,and T stage).Results Univariate analysis showed that,preoperative PLR>150,with/without portal vein tumor thrombus,tumor differentiation,and T stage,were closely related to MVI in patients with HCC(P<0.05).Multivariate Logistic regression analysis revealed that,preoperative PLR>150,tumor differentiation,and T stage were independent risk factors of MVI(P<0.05).The receiver operator characteristic(ROC)curve showed that,the areas under the curve(AUC)values of tumor differentiation,T stage,and PLR in predicting MVI were 0.694,0.721 and 0.748,respectively,with good predictive value of MVI.Conclusion Preoperative PLR>150,as an easily obtained inflammatory marker,may be an important factor in predicting the occurrence of postoperative MVI in HCC.