肠道菌群与急慢性胰腺炎的因果关系:一项双样本孟德尔随机化研究OACSTPCD

Objective To evaluate the association between gut microbiota and the risk of acute/chronic pancreatitis(AP/CP)using two-sample Mendelian randomization(TSMR)analysis.Methods The genome-wide association study(GWAS)data for AP/CP was obtained from the FinnGen consortium R10,and the GWAS data for gut microbiota was obtained from the research of Lopera-Maya,et al.Secondary data analysis was performed on all aggregated data based on GWASs,and the genetic loci closely associated with gut microbiota were selected as instrumental variables.The inverse variance weighted(IVW),MR-Egger regression,weighted median(WME)and weighted mode(WM)methods for TSMR analysis were employed in this study.Sensitivity analysis was used to test the robustness and reliability of MR results.The odds ratio(OR)was used to evaluate the relationship between gut microbiota and the risk of AP/CP.Results The correlation between 119 gut microbiota and AP/CP was analyzed in this study.The results showed that 5 genera were associated with AP,while 2 genera were associated with CP.The IVW method revealed that,Holdemania(OR=1.11,95%CI 1.02-1.21,P=0.019),Ruminococcus(OR=1.16,95%CI 1.02-1.32,P=0.020)and Barnesiella(OR=1.12,95%CI 1.00-1.24,P=0.046)were associated with increased risk of AP;Bacteroides(OR=0.89,95%CI 0.79-1.00,P=0.044)and Blautia(OR=0.82,95%CI 0.72-0.93,P=0.002)were associated with reduced risk of AP.Parabacteroides(OR=1.10,95%CI 1.00-1.22,P=0.038)was associated with increased risk of CP;Dorea(OR=0.79,95%CI 0.63-0.99,P=0.045)was associated with reduced risk of CP.Conclusion The TSMR analysis shows that,there may be a causal relationship between gut microbiota and the risk of AP/CP,regulation of gut microbiota may contribute to the prevention and treatment of AP/CP.