广州化学2024，Vol.49Issue(3)：17-24,8.DOI:10.16560/j.cnki.gzhx.20240301
二肽基肽酶-Ⅳ有机小分子荧光探针的研究进展
Progress in Dipeptidyl Peptidase-Ⅳ Organic Small Molecule Fluorescent Probes
摘要
Abstract
An essential transmembrane glycoprotein hydrolase,dipeptidyl peptidase-Ⅳ(DPP-Ⅳ)is intimately associated with a number of physiological functions and illnesses.Current research on biological enzyme detection is focused on organic small-molecule fluorescent probes,which have been published one after another for the detection of DPP-Ⅳ.For the first time,three types of organic small molecule fluorescent probes used for in vitro and in vivo detection and imaging of DPP-Ⅳ,namely,non-near-infrared fluorescent probes(λem<650 nm),near-infrared fluorescent probes(λem>650 nm),and two-photon fluorescent probes,were reviewed,and the design principles,structural features,and bioapplications of the three types of probes were compared and summarized,as well as their diagnostic applications in the diagnosis of DPP-Ⅳ-related diseases.Its application in the diagnosis of DPP-Ⅳ-related diseases,and discusses the challenges of DPP-Ⅳ activity detection in the future development direction.关键词
二肽基肽酶-Ⅳ/荧光探针/有机小分子/生物成像/研究进展Key words
dipeptidyl peptidase IV/fluorescent probe/small organic molecule/bioimaging/research progress分类
化学化工引用本文复制引用
杨政敏,钟甜甜,胡先运,韩忠耀,覃江克..二肽基肽酶-Ⅳ有机小分子荧光探针的研究进展[J].广州化学,2024,49(3):17-24,8.基金项目
国家自然科学基金项目(81860317) （81860317）
贵州省卫生健康委员会科学基金项目(zwkj2021-453) （zwkj2021-453）
黔南民族医学高等专科学校基金项目(Qnyz2021001,Qnyz2023001) （Qnyz2021001,Qnyz2023001）
